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Index / JaIC / Anti 4_HNE monoclonal antibody / Product Detail : MHN-100P Anti 4_HNE monoclonal antibody
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#MHN-100P Anti 4_HNE monoclonal antibody

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  Price : 595   EUR
676   USD
462   GBP
2503   Zloty
79728   JPY
4595   NOK
4923   SEK
673   CHF

Product name : Anti 4_HNE monoclonal antibody

Catalog number : MHN-100P

Quantity: 100 micro gram

Availability: Yes

Supplier name : JaIC

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About this Product :

Anti 4_HNE monoclonal antibody
Anti 4_HNE monoclonal antibody is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against. If used correctly and according the protocol, this antibody will provide excellent and reproducible results with guaranteed success for the tested and confirmed applications. Amongst the advantages of the monoclonal antibodies are: the fact that while the hybridoma takes a bit longer to be produced, once the line is ready there is virtually an endless supply of these antibodie throughout time with little to no variations in recognition sites of the antigen in different batches; in comparison to the polyclonal antibodies monoclonal antibodies are highly specific to a given epitope and can be used in applications where specific targeting is required.

More Details about

Anti thymidineglycol monoclonal antibody (clone 2E8)
Suitable for immunohistocheistry. For research use only.
[ Specific to DNA oxidation ]
Thymidineglycol (TG) is one of the major oxidation products of DNA. Thymidine (T) can be damaged by oxidative stress such as radiation and energy metabolism. Two different pathways to form TG have been suggested. Deoxythymidine in DNA is directly oxidised by hydroxy radical, to form TG. TG can be also formed through an intermediate thymidine chlorohydrin, which is derived from hypochlorous acid (HOCl) from neutrophil myeloperoxidase. Thymidineglycol is derived from DNA, not from RNA. TG is the oxidative stress marker secific for DNA damage.
[ Comparison with 8-OHdG ]
8-hydroxy-2'-deoxyguanosine (8-OHdG) is one of the well-known DNA oxidation products. In an lipopolysaccharide (LPS)-treated mouse liver, 8-OHdG can be stained in 24 hours after LPS treatment. TG can be detected in 6 hours, and remain at least for 72 hours. Anti TG monoclonal antibody (clone 2E8) has been established by Dr. Toshihiko Osawa (Nagoya Univ.). Poly dT (50 mer) has been oxidised by OsO4 and injected to Balb/c mouse as immunogen. This antibody can react with thymidineglycol in DNA or TG polymer, and suitable for immunohistochemistry.
[ Specifications ]
Antigen: Thymidineglycol polymer.
Form: Lyophilized power. Reconstitute by 1000 µL of distilled water. 100 µg/mL of IgG.
Subclass: Mouse IgG1 (kappa), clone 2E8
Specificity: Specific for DNA fragment containing thymidine glycol, and thymidine glycol polymer.
Cross reactivity have been tested to following analogues: oxidized deoxycytidine polymer, oxidized deoxyguanosine polymer and oxidized deoxyadenosine polymer. Not react with free thymidineglycol.
Application: Immunohistochemistry (antibody conc. 5 - 10 µg/mL)
Storage: Less than -20°C
1) Ito K, Yano T, Morodomi Y, Yoshida T, Kohno M, Haro A, Shikada Y, Okamoto T, Maruyama R, Maehara Y.
Serum antioxidant capacity and oxidative injury to pulmonary DNA in never-smokers with primary lung cancer.
Anticancer Res. 32(3),p1063-1067(2012)     


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