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Index / FabGennix / Protein kinase B antibody, Host species: Rabbit, Polyclonal antibody / Product Detail : AKT-101AP Protein kinase B antibody, Host species: Rabbit, Polyclonal antibody
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Sep
24th

#AKT-101AP Protein kinase B antibody, Host species: Rabbit, Polyclonal antibody

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  Price : 449   EUR
510   USD
348   GBP
1887   Zloty
60118   JPY
3465   NOK
3712   SEK
508   CHF

Product name : Protein kinase B antibody, Host species: Rabbit, Polyclonal antibody

Catalog number : AKT-101AP

Quantity: 200ul

Availability: Yes

Supplier name : FabGennix

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About this Product :

Protein kinase B antibody, Host species: Rabbit, Polyclonal antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Protein kinase B antibody, Host species: Rabbit, Polyclonal antibody .
http://mybiofast.com/ver.php?search=anti-&submit=Search

Protein kinase B antibody, Host species: Rabbit, Polyclonal antibody rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. Do not freeze taw, rather use Protein kinase B antibody, Host species: Rabbit, Polyclonal antibody from the fridge if your use is less than 1 or 2 weeks.
http://mybiofast.com/ver.php?search=rabbit&submit=Search

More Details about

Cell signaling mechanisms often transmit information via posttranslational protein modifications, most importantly reversible protein phosphorylation mediated by protein kinases.   AKT (also called protein kinase B) is a serine-threonine kinase that is activated downstream of growth factor receptors. It is a key player in signaling pathways that regulate energy metabolism, proliferation, and cell survival (1).  AKT1 was first described as the cellular homologue of the product of v-akt oncogene.  Protein kinase B, also known as Akt was first described as the cellular homologue of the product of the v-akt oncogene.  PKB comprise an N-terminal pleckstrin homology (PH) domain, a flexible hinge between the PH and the kinase domain, a catalytic (kinase) domain, and a C-terminal regulatory part (containing a hydrophobic motif, or HM).  Activation of AKT depends upon the integrity of PH homology domain, which mediates its membrane translocation and the phosphorylation of Thr308 in the activation loop and Ser473 (2).    AKT is a direct substrate of protein tyrosine kinase 6, that is not expressed in normal cells but induced in mammary cancer cells, phosphorylates AKT at Tyrosine residues Y315 and Y326.  

Protein kinase B is expressed in three isoforms (PKBalpha/AKT1, PKBbeta/AKT2 and PKBgamma/AKT3), AKT1 is expressed in multiple spliced variant forms.  The AKT1  gene is catalytically yin active but selectively activated by PDGF and the activation is abrogated by mutations in the PH domain.  The activation involves the IP3 kinase. Understanding the regulation of Akt has been of major interest for elucidating the control of normal cellular physiology as well as malignant transformation. The activation of Akt involves phosphatidylinositol 3-kinase-dependent membrane localization followed by activating phosphorylation of Thr-308 and Ser-473. Many of the activating signals for Akt involve the stimulation of receptor and non-receptor tyrosine kinases, and the most potent activator known is the tyrosine phosphatase inhibitor pervanadate, highlighting a possible role for tyrosine phosphorylation in the regulation of the enzyme (3).  PKB is a 60 kDa protein expressed in majority of cells, mutations in this gene lead to proteus syndrome.  .

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