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Index / FabGennix / Glucose Transporter Type 12 antibody, Host species: Rabbit, Polyclonal antibody / Product Detail : Glut-1201AP Glucose Transporter Type 12 antibody, Host species: Rabbit, Polyclonal antibody
#Glut-1201AP Glucose Transporter Type 12 antibody, Host species: Rabbit, Polyclonal antibody
Product name : Glucose Transporter Type 12 antibody, Host species: Rabbit, Polyclonal antibody
Catalog number : Glut-1201AP
Supplier name : FabGennix
Data sheet: Ask more or other datasheet now !
About this Product :Glucose Transporter Type 12 antibody, Host species: Rabbit, Polyclonal antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Glucose Transporter Type 12 antibody, Host species: Rabbit, Polyclonal antibody .
Glucose Transporter Type 12 antibody, Host species: Rabbit, Polyclonal antibody rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. Do not freeze taw, rather use Glucose Transporter Type 12 antibody, Host species: Rabbit, Polyclonal antibody from the fridge if your use is less than 1 or 2 weeks.
More Details about
Thirteen different types of glucose/fructose transport carrier proteins designated as Glut 1-13 facilitate glucose/fructose transport across the cell membrane. Molecular cloning of glucose transporters have identified a family of closely related genes that encodes at least 7 proteins exhibiting high degree of amino acid homology (45%-65%) all in the molecular weight range of 40-84kDa. Individual members of the Glut family have predicted secondary structure characteristic of 12 membrane spanning domains of other transport carriers. Majority of the differences in sequence homology in Glut proteins occur at 4 hydrophilic domains that may play a role in distinct tissue-specific pattern of expression and targeting. All Glut proteins are glycosylated at or near the C-terminus and are present on either cell surface or in intracellular sites. Some transporters exhibit dynamic trafficking between intracellular storage sites and plasma membranes in response to various stimuli. In some tissues Glut proteins are asymmetrically distributed between apical and basolateral membranes as in blood brain barrier and blood testis barriers.
The Glut family-selective antibodies were generated against unique C-terminal peptides characteristics of a particular Glut family. FabGennix Inc. has generated highly specific rabbit anti-Glut 12 polyclonal antibodies utilizing C-terminal sequences. These antibodies have been fully characterized for cross reactivity within the Glut family and with other cellular proteins. FabGennix Inc. has produced antibodies to multiple epitopes on the same protein that will facilitate studies utilizing interspecies cross reactivity.
FabGennix Inc. provides Glut 10 Western blot positive control in “ready to use” SDS-PAGE sample buffer. The Glut 12 positive control appears as a diffuse band of 80-82 kDa on a 10% SDS-PAGE. The Glut 12-selective antibodies were generated against synthetic peptides form unique regions on the C-terminal end of Glut 12 protein. The Glut 10 peptide was post-synthetically modified to achieve the desired antigenicity before injecting in to rabbits to obtained antibodies. The antibodies were isolated on an immobilized antigen based affinity matrix before stabilizing them in antibody stabilization buffer. The Glut 12 antibodies label Glut 12 protein at 80-82kDa band in PC-Glut12 samples. FabGennix Inc. provides Western blot positive controls for Glut 12 in ready-to-use buffer for SDS-PAGE and western blotting applications. FabGennix International Inc., has also produced antibodies to other members of solute carrier proteins for a complete listing please visit www.FabGennix.com. Limited quantities of antigenic blocking peptide for Glut 12 antibody is also available (Inquire before placing orders). FabGennix International Inc., will conjugate and couple these antibodies to fluorescent probes and secondary enzymes at a nominal price.
Applications: ELISA Antibody dilution 1:4,500 for ELISA or DOT blot with solublized hippocampal plasma membranes.
W.B Antibody dilution 1:500 for WB using PC-Glut 12 samples as antigen.
IMM 2.5ul of Glut-1001AP will immunoprecipitate 65-70% Glut12 from solObuffer solubilized cell extracts; IHC n.d
Reactivity The antibodies (Glut-1201AP) label glucose transporter (Glut12) in rat, mouse and human cell extracts.
Protocols: Standard protocol for various applications (Western blot; immunoprecipitation and immunohistochemistry) of this antibody is provided with the product specification sheet, however, FabGennix Inc. strongly recommends investigators to optimize conditions for use of this antibody in their laboratories.
WB, Western Blot analyses; IMM, Immunoprecipitation; IHC, Immunohistochemistry, n.d, not determine.
Form/Storage: The antiserum is supplied in antibody stabilization buffer with preservatives. The affinity purified antibodies are isolated on antigen-speharose affinity column. Antibodies are supplied as 1 mg/ml IgG in antibody stabilization buffer with preservatives. For long-term storage of antibody, store at -20oC. FabGennix Inc. does not recommend storage of very dilute antibody solutions unless they are prepared in specially formulated multi use antibody dilution buffer (Cat # DiluOBuffer). Working solutions of antibodies in DiluOBuffer should be filtered through 0.45ƒÝ filter after every use for long-term storage.
1. Meuckler M. M., NIPS, 10, 22-29, 1995.
2. Farooqui S. M., Bagdadi A. F., Rhett S., and O’Donnell J. M., Biochem. Biophys. Res. Comm. 236, 407-412, 1997.
*Note: Do not heat or boil Glut 12-PC samples. This product is “ready to use” for electrophoresis. After thawing at room temperature. Repeated freezing and thawing may result in appearance of higher molecular weight immunoreactive bands.
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WP1017: Type II interferon signaling (IFNG)
WP109: UDP-Glucose Conversion
WP1136: Type II interferon signaling (IFNG)
WP1253: Type II interferon signaling (IFNG)
WP1289: Type II interferon signaling (IFNG)
WP1350: Type II interferon signaling (IFNG)
WP1455: Serotonin Transporter Activity
WP1493: Carbon assimilation C4 pathway
WP1584: Type II diabetes mellitus
WP1616: ABC transporters
WP1680: Oxidative phosphorylation
WP1688: Polyketide sugar unit biosynthesis
WP1689: Porphyrin and chlorophyll metabolism
WP1703: Streptomycin biosynthesis
WP1713: Two-component system
WP1935: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
WP2061: Fates of Glucose-6-P
WP2113: Type III interferon signaling
WP2248: anthocyanin biosynthesis
WP2272: Pathogenic Escherichia coli infection
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP2345: vitamin B7 (biotin) biosynthesis pathway
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
Related Genes :
[G6PD] Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 22.214.171.124)
[SLC2A1 GLUT1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)
[G6PC G6PT] Glucose-6-phosphatase (G-6-Pase) (G6Pase) (EC 126.96.36.199) (Glucose-6-phosphatase alpha) (G6Pase-alpha)
[SLC37A4 G6PT G6PT1 PRO0685 TRG19] Glucose-6-phosphate exchanger SLC37A4 (Glucose-5-phosphate transporter) (Glucose-6-phosphate translocase) (Solute carrier family 37 member 4) (Transformation-related gene 19 protein) (TRG-19)
[TP53 P53] Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
[GPI] Glucose-6-phosphate isomerase (GPI) (EC 188.8.131.52) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36)
[GALT] Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (EC 184.108.40.206) (UDP-glucose--hexose-1-phosphate uridylyltransferase)
[SLC2A4 GLUT4] Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
[G6PC3 UGRP] Glucose-6-phosphatase 3 (G-6-Pase 3) (G6Pase 3) (EC 220.127.116.11) (Glucose-6-phosphatase beta) (G6Pase-beta) (Ubiquitous glucose-6-phosphatase catalytic subunit-related protein)
[HSPA5 GRP78] 78 kDa glucose-regulated protein (GRP-78) (Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)
[AKT1 PKB RAC] RAC-alpha serine/threonine-protein kinase (EC 18.104.22.168) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
[Slc2a4 Glut-4 Glut4] Solute carrier family 2, facilitated glucose transporter member 4 (GT2) (Glucose transporter type 4, insulin-responsive) (GLUT-4)
[Slc2a4 Glut-4 Glut4] Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
[PGM2 GA-5 GAL5 YMR105C YM9718.04C] Phosphoglucomutase 2 (PGM 2) (EC 22.214.171.124) (D-glucose-1,6-diphosphate:D-glucose-1-phosphate phosphotransferase) (Glucose phosphomutase 2)
[RHM2 MUM4 At1g53500 F22G10.13 T3F20.18] Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2 (NDP-rhamnose synthase) (Protein MUCILAGE-MODIFIED 4) (Protein RHAMNOSE BIOSYNTHESIS 2) (Rhamnose biosynthetic enzyme 2) (AtRHM2) (UDP-L-rhamnose synthase MUM4) [Includes: UDP-glucose 4,6-dehydratase (EC 126.96.36.199); UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose 4-keto-reductase (EC 1.1.1.-) (EC 5.1.3.-)]
[SLC5A1 NAGT SGLT1] Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)
[Slc2a1 Glut-1 Glut1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (GT1)
[PDX1 IPF1 STF1] Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1)
[SIRT1 SIR2L1] NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
[RHM1 ROL1 At1g78570 T30F21.10] Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1 (Protein REPRESSOR OF LRX1 1) (Rhamnose biosynthetic enzyme 1) (AtRHM1) [Includes: UDP-glucose 4,6-dehydratase (EC 188.8.131.52); UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose 4-keto-reductase (EC 1.1.1.-) (EC 5.1.3.-)]
[FBN1 FBN] Fibrillin-1 [Cleaved into: Asprosin]
[zwf] Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 184.108.40.206)
[UFGT AlUFGT1 AlUFGT2 FlUFGT1 FlUFGT2 ITUFGT1 ITUFGT2 RUUFGT1 RUUFGT2 VVGT1 GSVIVT00014047001 LOC100233099 VITISV_008354] Anthocyanidin 3-O-glucosyltransferase 2 (EC 220.127.116.11) (Flavonol 3-O-glucosyltransferase) (UDP-glucose flavonoid 3-O-glucosyltransferase)
[UGP2 UGP1] UTP--glucose-1-phosphate uridylyltransferase (EC 18.104.22.168) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase)
[gdh] Glucose 1-dehydrogenase (GDH) (GlcDH) (EC 22.214.171.124) (Aldose 1-dehydrogenase [NAD(P)(+)]) (EC 126.96.36.1999) (Galactose 1-dehydrogenase) (EC 188.8.131.52) (EC 184.108.40.206)
[SLC2A2 GLUT2] Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2)
[HXK1 GIN2 At4g29130 F19B15.160] Hexokinase-1 (EC 220.127.116.11) (Protein GLUCOSE INSENSITIVE 2)
[Sirt1 Sir2l1] NAD-dependent protein deacetylase sirtuin-1 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
[ptsG glcA umg b1101 JW1087] PTS system glucose-specific EIICB component (EIICB-Glc) (EII-Glc) [Includes: Glucose permease IIC component (PTS system glucose-specific EIIC component); Glucose-specific phosphotransferase enzyme IIB component (EC 18.104.22.168) (PTS system glucose-specific EIIB component)]
[G6PC2 IGRP] Glucose-6-phosphatase 2 (G-6-Pase 2) (G6Pase 2) (EC 22.214.171.124) (Islet-specific glucose-6-phosphatase catalytic subunit-related protein)
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