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Index / FabGennix / Interferon inducible protien 27, Host species: Rabbit, Polyclonal antibody / Product Detail : IFI27-101AP Interferon inducible protien 27, Host species: Rabbit, Polyclonal antibody
#IFI27-101AP Interferon inducible protien 27, Host species: Rabbit, Polyclonal antibody
Product name : Interferon inducible protien 27, Host species: Rabbit, Polyclonal antibody
Catalog number : IFI27-101AP
Supplier name : FabGennix
Data sheet: Ask more or other datasheet now !
About this Product :Interferon inducible protien 27, Host species: Rabbit, Polyclonal antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Interferon inducible protien 27, Host species: Rabbit, Polyclonal antibody .
Interferon inducible protien 27, Host species: Rabbit, Polyclonal antibody rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. Do not freeze taw, rather use Interferon inducible protien 27, Host species: Rabbit, Polyclonal antibody from the fridge if your use is less than 1 or 2 weeks.
More Details about
Treatment of breast carcinoma MCF7cells with estradiol led to induction of a new 27 kDa protein, the cDNA was later cloned and identified as p27. This highly hydrophobic protein of 122 amino acids has 33% over all sequence similarity to the product of the 6-16 gene (1), that is induced by alfa/beta type interferons. It has been shown that p27is transcriptionaly induced by interferon alfa in various human cell lines. The induction induced by interferon alfa is independent of the presence of estradiol receptors on the cells. High levels of p27 mRNA, detected by Northern blotting, was found in 50% of the primary breast carcinoma cells, suggesting p27 can be a diagnostic marker for breast carcinoma detection (2). Examination of p27 expression by in situ hybridization in p27 over expressing tumors suggest that p27 gene is localized in cancer cells and some times also in fibroblastic cells of tumor stroma. IFI27 mRNA expression is highly up-regulated in lesional psoriatic epidermis and in non-lesional keratinocytes. It was also expressed in lichen planus, chronic eczema, cutaneous squamous cell cancers, and during normal wound repair when IFI27 was found in the proliferating subpopulation of keratinocytes (3). P27 Further studies are now necessary to elucidate the cause of p27 gene overexpression in breast carcinoma and in particular to determine whether it corresponds to chromosomal rearrangements in the 14q32 region and/or to induction by interferons of the alpha/beta type.
P27 protein is highly hydrophobic, containing 2 trans-membrane spanning regions localized on human chromosome in band q32. The apparent molecular weight of IFI27 is 26-29 kDa on reduced SDS-PAGE. IFI induced proteins like P27 and P16 genes have also showed potential targets for anti-angiogenic therapy employing INFs.
The IFI27-selective antibodies were generated in rabbits against unique N, and C-terminal peptides that are unique to P27 IFI27 protein, the C-terminal peptide antibodies (IFI-112AP) will also label the short splice variant of the IFI27 protein (p16). FabGennix Inc. has generated specific rabbit anti-IFI27 antibodies using linear and multiple antigenic peptide (MAP) methodology. These antibodies have been characterized by ELISA and dot blot assays using various breast cancer cell lines.
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WP1017: Type II interferon signaling (IFNG)
WP1136: Type II interferon signaling (IFNG)
WP1253: Type II interferon signaling (IFNG)
WP1289: Type II interferon signaling (IFNG)
WP1313: Insulin Signaling
WP1321: Myometrial Relaxation and Contraction Pathways
WP1350: Type II interferon signaling (IFNG)
WP1354: B Cell Receptor Signaling Pathway
WP1365: Calcium Regulation in the Cardiac Cell
WP1371: G Protein Signaling Pathways
WP153: Urea cycle and metabolism of amino groups
WP1835: Interferon alpha/beta signaling
WP1836: Interferon gamma signaling
WP1837: Interferon Signaling
WP1995: Effects of nitric oxide
WP2113: Type III interferon signaling
WP2119: Interferon induced apoptosis
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP2353: vitamin B9 (folate) biosynthesis pathway
WP426: Urea cycle and metabolism of amino groups
WP497: Urea cycle and metabolism of amino groups
WP585: Interferon type I
WP619: Type II interferon signaling (IFNG)
Related Genes :
[EIF2AK2 PKR PRKR] Interferon-induced, double-stranded RNA-activated protein kinase (EC 126.96.36.199) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 188.8.131.52) (p68 kinase)
[IFI16 IFNGIP1] Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator)
[IFNG] Interferon gamma (IFN-gamma) (Immune interferon)
[IFNAR2 IFNABR IFNARB] Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)
[IRF3] Interferon regulatory factor 3 (IRF-3)
[MAVS IPS1 KIAA1271 VISA] Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
[IRF7] Interferon regulatory factor 7 (IRF-7)
[TMEM173 ERIS MITA STING] Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)
[interferon-beta-1 IFN-beta IFNB IFNB1 interferon-beta/ poIFN-beta] Interferon beta (Interferon-beta) (Interferon-beta-1) (Uncharacterized protein)
[MX1] Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed]
[IFNAR1 IFNAR] Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
[IL6 IFNB2] Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
[IFIH1 MDA5 RH116] Interferon-induced helicase C domain-containing protein 1 (EC 184.108.40.206) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)
[ADAR ADAR1 DSRAD G1P1 IFI4] Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 220.127.116.11) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP)
[PRKRA PACT RAX HSD-14 HSD14] Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator)
[IFNA2 IFNA2A IFNA2B IFNA2C] Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A)
[Eif2ak2 Pkr Prkr Tik] Interferon-induced, double-stranded RNA-activated protein kinase (EC 18.104.22.168) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 22.214.171.124) (p68 kinase)
[Tmem173 Eris Mita Mpys Sting] Stimulator of interferon genes protein (mSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (MMITA) (Transmembrane protein 173)
[ISG15 G1P2 UCRP] Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP)
[IRF1] Interferon regulatory factor 1 (IRF-1)
[Ifnar1 Ifar Ifnar] Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Type I interferon receptor 1)
[IFNB1 IFB IFNB] Interferon beta (IFN-beta) (Fibroblast interferon)
[Ifng] Interferon gamma (IFN-gamma)
[IFNGR2 IFNGT1] Interferon gamma receptor 2 (IFN-gamma receptor 2) (IFN-gamma-R2) (Interferon gamma receptor accessory factor 1) (AF-1) (Interferon gamma transducer 1)
[IFIT5 ISG58 RI58] Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)
[Irf7] Interferon regulatory factor 7 (IRF-7)
[IRF4 MUM1] Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)
[IRF5] Interferon regulatory factor 5 (IRF-5)
[IFITM1 CD225 IFI17] Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225)
[IFITM3] Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Interferon-inducible protein 1-8U)
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