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Index / FabGennix / PDE4, Host species: Rabbit, Polyclonal antibody / Product Detail : PD4-101AP PDE4, Host species: Rabbit, Polyclonal antibody
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Dec
7th

#PD4-101AP PDE4, Host species: Rabbit, Polyclonal antibody

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  Price : 410   EUR
466   USD
318   GBP
1725   Zloty
54965   JPY
3168   NOK
3394   SEK
464   CHF

Product name : PDE4, Host species: Rabbit, Polyclonal antibody

Catalog number : PD4-101AP

Quantity: 200ul

Availability: Yes

Supplier name : FabGennix

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About this Product :

PDE4, Host species: Rabbit, Polyclonal antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of PDE4, Host species: Rabbit, Polyclonal antibody .
http://mybiofast.com/ver.php?search=anti-&submit=Search

PDE4, Host species: Rabbit, Polyclonal antibody rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. Do not freeze taw, rather use PDE4, Host species: Rabbit, Polyclonal antibody from the fridge if your use is less than 1 or 2 weeks.
http://mybiofast.com/ver.php?search=rabbit&submit=Search

More Details about

C

 

yclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases.  cAMP-specific phosphodiesterase type-4 (PDE4) family is comprised of 4 genes (PDE4 A, B, C and D) with multiple splice variants generated by RNA splicing and use of alternate initiation sites (1).  The cAMP-dependent protein kinase A modulates the enzyme activity of some PDE4 family members by phosphorylation/dephosphorylation mechanisms (2, 3).   Such short-term regulatory mechanisms are necessary for rapid changes in the cAMP levels in cells.  PDE4-family selective inhibitor, rolipram inhibits all members of the PDE4 family in mM range.  At present PDE4 subtype selective and variant selective inhibitors are not available.  In rodents inhibition of PDE4 enzymes by rolipram attenuated short- and long-term memory impairment produced by the administration of scopolamine and MK801 (3, 4).  Interaction of these enzymes with cellular scaffolding proteins plays important role in PDE4 compartmentalization and cAMP-dependent signaling.  Members of the PDE4A and D subtype variants specifically interact with cytoskeletal proteins with SH3 domains or RACK and AKAP for cellular compartmentalization.  In brain PDE4A, B and D are associated with GPCRs signaling (5, 6). 

The PDE4 family-selective antibody was generated against a common sequence near the C-terminal end that is unique to PDE4 family members.  The polyclonal antibody labels PDE4A and PDE4D variants in rat brain and has low affinity for PDE4B variants (7).  FabGennix Inc. provides PDE family selective, family subtype-selective and family-subtype-variant selective antibodies for detailed analyses of cAMP signaling pathways.  The PDE4 selective-antibody (PD4-100P/101AP) was generated using cyclic peptide methodology that results in higher titer and specificity (6). Antibody PD4-100P and PD4-101AP label all known PDE4 A and D variants including PDE4A1, A5, Ax, A8 and PDE4D1-D5.  PDE4-selective antibody is also available in affinity purified form for confocal, Western blotting and immunohistochemical (IHC) analyses .  FabGennix Inc. will also conjugate antibodies with fluorescent probes upon request at extra charge.  

For research use only, not for diagnostic or therapeutic use.

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