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Index / FabGennix / PDE5A , Host species: Rabbit, Polyclonal antibody / Product Detail : PD5A-101AP PDE5A , Host species: Rabbit, Polyclonal antibody
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  Price : 410   EUR
466   USD
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54965   JPY
3168   NOK
3394   SEK
464   CHF

Product name : PDE5A , Host species: Rabbit, Polyclonal antibody

Catalog number : PD5A-101AP

Quantity: 200ul

Availability: Yes

Supplier name : FabGennix

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About this Product :

PDE5A , Host species: Rabbit, Polyclonal antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of PDE5A , Host species: Rabbit, Polyclonal antibody .

PDE5A , Host species: Rabbit, Polyclonal antibody rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. Do not freeze taw, rather use PDE5A , Host species: Rabbit, Polyclonal antibody from the fridge if your use is less than 1 or 2 weeks.

More Details about

The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP]) are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G-protein coupled receptors (GPCRs) for hormones, cytokines, and neurotransmitters.  Cyclic nucleotides are important intracellular second messengers which play important role in a variety of signal transduction process.  The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases.  One of the many phosphodiesterases that compartmentalized and hydrolyze cGMP in various tissues is phosphodiesterase type 5A.  The cGMP is involved in nitric oxide signaling as well as cell signaling associated with natriuretic peptides and gulanylins.  Some of the intracellular biding cites for the cGMP include cyclic nucleotide gated ion channels, cGMP-dependent protein kinases, and cyclic GMP biding phosphodiesterases (cGB-PDEs).  The cGB-PDEs include PDE2, PDE3, PDE5, PDE5 and PDE10; the members of these families contain various structural and functional motifs that are conserved.  Most of these proteins contain dimmeric subunits that contain a highly conserved cGMP binding site and a phosphodiesterase catalytic site.  The cGMP-specific phosphodiesterase type-5A (PDE5A) family is comprised of single gene with multiple splice variants (PDE5A1 and PDE5A2) generated by RNA splicing and use of alternate initiation sites (1, 2).  The PDE5 is highly expressed in aorta and lungs, intestine, kidney adrenal gland cerebellum and cerebrum.  In cerebellum the PDE5 is highly expressed during neonatal development in Purkinge cells layer.  The PDE5 is also abundant in vascular smooth muscle regulating cGMP levels and vascular smooth muscle tonicity.  In corpus cavernosum inhibition of PDE5 by sildenafil corrects erectile dysfunctions.  The nitric oxide donor sodium notropurside (SNP) stimulate PDE5 activity by cGMP-dependent kinase phosphorylation (Rybalkin et. al., 2002; Murthy 2001).  PDE5A1 has 875 amino acids (99.5 kDa).  The amino terminal 142 amino acid of the PDE5 gene showed no sequence homology with other PDEs and also contained serine 92 that is phosphorylated by cGMP-kinases (McAllister et al., 93).
FabGennix Inc. also provides antibodies to other PDE family members.  Our PDE series antibodies are selective for PDE families, family subtype-selective and family-subtype-variant selective for detailed analyses of cyclic nucleotide signaling pathways.  The PDE5-selective antibodies (PD5A-100P and PD5A-101AP) are generated against peptides from unique sequences on the PDE5A gene.  The affinity purified antibody (PD5A-101AP) labels 99 and 89 kDa PDE5A1 and PDE5A2 proteins using PDE5A WB positive controls (Cat # PC-PD5A).  The PDE5A-specific antiserum has no cross reactivity against PDE5B protein or any other member of the fast growing family of PDEs.
The PDE5-selective antibody (PD5A-100P/101AP) was generated using cyclic peptide methodology that results in higher titer and specificity (3).  PDE5A-selective antibody is also available in affinity purified form for confocal, WB & IHC analyses.  

For research use only, not for diagnostic or therapeutic use.

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