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Index / BPS Bioscience / Nrf antioxidant pathway ARE reporter cell line / Product Detail : 60513 Nrf antioxidant pathway ARE reporter cell line
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Aug
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#60513 Nrf antioxidant pathway ARE reporter cell line

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  Price : 7830   EUR
8886   USD
6073   GBP
32887   Zloty
1047498   JPY
60373   NOK
64691   SEK
8854   CHF

Product name : Nrf antioxidant pathway ARE reporter cell line

Catalog number : 60513

Quantity: 1.5x10(6) cells

Availability: Yes

Supplier name : BPS Bioscience

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About this Product :

Nrf antioxidant pathway ARE reporter cell line antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Nrf antioxidant pathway ARE reporter cell line.
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More Details about

Product Description
The Nrf2 antioxidant response pathway plays an important role in cellular antioxidant
defense. Nrf2, a basic leucine zipper transcription factor, induces the expression of
antioxidant and phase II enzymes by binding to the ARE (antioxidant response element)
region of the gene promoter. Under basal conditions, Nrf2 is retained in the cytosol by
binding to the cytoskeletal protein Keap1. Upon exposure to oxidative stress or other
ARE activators, Nrf2 is released from Keap1 and translocates to the nucleus, where it
can bind to the ARE, leading to the expression of antioxidant and phase II enzymes that
protect the cell from oxidative damage. 
The ARE Reporter – Hep G2 cell line contains a firefly luciferase gene under the control
of ARE stably integrated into Hep G2 cells. This cell line is validated for the response to
the stimulation of tert-butylhydroquinone and sulforaphane.

Application
• Monitor Nrf2 antioxidant response pathway activity.
• Screen for activators or inhibitors of Nrf2 antioxidant response pathway.

Format
Each vial contains ~2 X 106 cells in 1 ml of 10% DMSO.

Storage
Immediately upon receipt, store in liquid nitrogen.

References
1. Lee, JM et. al. (2004) An important role of Nrf2-ARE pathway in the cellular
defense mechanism. J Biochem Mol Biol. 37(2): 139-143.
2. Dinkova-Kostova, AT et.al. (2002) Direct evidence that sulfhydryl groups of
Keap1 are the sensors regulating induction of phase 2 enzymes that protect
against carcinogens and oxidants. Proc Natl Acad Sci U S A. 99(18): 11908-
11913.

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