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Index / Arbor / Cystatin C Immunoassay Kit / Product Detail : K012-H1 Cystatin C Immunoassay Kit
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Dec
8th

#K012-H1 Cystatin C Immunoassay Kit

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  Price : 350   EUR
398   USD
272   GBP
1474   Zloty
46949   JPY
2706   NOK
2899   SEK
396   CHF

Product name : Cystatin C Immunoassay Kit

Catalog number : K012-H1

Quantity: 1x96 well plate

Availability: Yes

Supplier name : Arbor

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More Details about

FEATURES

  •  
  • USE - Kidney Injury Marker, Results in 2 Hours
  • SAMPLE - Serum, Plasma, Urine or TCM
  • SAMPLES/KIT - 40 in Duplicate
  • STABILITY - Stable 4˚C Liquid Reagents

DESCRIPTION

The DetectX® Cystatin C Immunoassay Kit is designed to measure Human Cystatin C levels in a variety of biological matrices. This kit uses a microtiter plate coated with a monoclonal to Cystatin C and a native human Cystatin C molecule standard. Samples and standards are added to the plate and after an hour incubation at RT the plate is washed and monoclonal antibody-peroxidase conjugate is added. After a 30-minute incubation at RT, the plate is washed and TMB substrate solution added to each well. The color reaction is read at 450nm.

Cystatin C is a non-glycosylated protein of low molecular weight (13kDa) in the cystatin superfamily. Cystatin C is produced at a constant rate in all nucleated cells. Cystatin C belongs to the cysteine proteinase inhibitor group and is associated with several pathological conditions. Imbalance between Cystatin C and cysteine proteinases is associated with diseases such as inflammation, renal failure, cancer, Alzheimer’s disease, multiple sclerosis and hereditary Cystatin C amyloid angiopathy. Cystatin C is removed from blood plasma by glomerular filtration in the kidneys. It is reabsorbed by the proximal tubular cells and degraded. There is a linear relationship between the reciprocal Cystatin C concentration in plasma and the glomerular filtration rate (GFR). Cystatin C is suggested to be a better marker for GFR than other markers as its serum concentration is not affected by other factors such as age, gender and body mass. There is association of Cystatin C levels with the incidence of myocardial infarction and coronary death, presenting a risk factor for secondary cardiovascular events.

Cystatin C Standard Curve

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