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Index / Biovis / Caspase_3 proform, human recombinant / Product Detail : 1083P-5 Caspase_3 proform, human recombinant
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Sep
27th

#1083P-5 Caspase_3 proform, human recombinant

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  Price : 525   EUR
596   USD
407   GBP
2206   Zloty
70281   JPY
4050   NOK
4340   SEK
594   CHF

Product name : Caspase_3 proform, human recombinant

Catalog number : 1083P-5

Quantity: 5 ug

Availability: Yes

Supplier name : Biovis

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About this Product :

Caspase_3 proform, human recombinant recombinant proteins Most stable storage is at - 81 C or lower but some lyophilised proteins can be stored at +4C. Please read carefully the data sheet of the Caspase_3 proform, human recombinant.
http://mybiofast.com/ver.php?search=rec.&submit=Search

Caspase_3 proform, human recombinant Human samples 80 % of the research is conducted on human samples. GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Caspase_3 proform, human recombinant.
http://mybiofast.com/ver.php?search=human+&submit=Search

More Details about

AMOUNT: 5 μg
PURITY: >90% by SDS-PAGE
FORM: Lyophilized powder
RECONSTITUTION: Reconstitute to 0.1 μg/μl in PBS containing 15% glycerol.


STORAGE:
Store at –70°C. After initial reconstitution, aliquot product into individual tubes and immediately refreeze at –70°C. AVOID FREEZE/THAW CYCLES!


BACKGROUND DESCRIPTION:
Caspase-3 (also know as CPP32, Yama and apopain) is a member of the caspase family of cysteine proteases. Caspase-3 exists in cells as an inactive 32 kDa proenzyme. Proteolytic processing of this inactive proenzyme generates the 17 kD and 12 kD subunits which, when assembled as a tetramer (a pair of heterodimers), form the active caspase. Cascades of caspase activation have been shown to be key signal-transducing events in apoptosis.
Procaspase-3, like other procaspases with short N-terminal prodomains, is considered to be a downstream or “effector” enzyme. Pro-caspase-3 can be cleaved and activated by caspase-8 and –10 which are themselves activated through interaction with death ligand receptor/adapter protein complexes (e.g., Fas/FADD). Procaspase-3 is also processed by caspase-9, the apical caspase that is activated by binding to the Apaf-1/cytochrome c/ATP “apoptosome”. Thus, activation of procaspase-3 stands at a point of convergence for the two major types of apoptosis signaling pathways-those linked to cell surface death receptors and those linked to mitochondrial release of cytochrome c.
The recombinant Procaspase-3 (1083P-5) is produced by expression of a human cDNA in E. coli. The purified protein is highly activatable by treatment with active recombinant caspase-8 (1088-25, -100). We routinely test the activation using 10-30 ng of the procaspase-3 treated with 0.1-0.5 units of the active recombinant caspase-8 in 100 μl of Reaction Buffer (1068-20) for 30 minutes. Activation of procaspase-3 can be monitored using the Caspase-3 Fluorometric and Colorimetric Assay Kits (K105 and K106).


For Research Use Only! Not to be used in humans.

 

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