GENTAUR Molecular Products.
Monoclonal Antibody, ELISA Kit, Polyclonal Antibody, Recombinant/Purified Protein.
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Index / Biovis / Cyclopamine / Product Detail : 1578-5 Cyclopamine
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Apr
21th
#1578-5 Cyclopamine
| Price : | 262 | EUR |
| 297 | USD | |
| 203 | GBP | |
| 1101 | Zloty | |
| 35069 | JPY | |
| 2021 | NOK | |
| 2165 | SEK | |
| 296 | CHF |
Product name : Cyclopamine
Catalog number : 1578-5
Quantity: 5 mg
Availability: Yes
Supplier name : Biovis
Data sheet: Ask more or other datasheet now !
More Details about
Alternate Name/Synonyms: 11-deoxojervine
Appearance: Off-white solid
Formulation: N/A
CAS Number: 4449-51-8
Molecular Formula: C₂₇H₄₁NO₂
Molecular Weight: 411.62
Purity: ≥99%
Solubility: DMSO (4 mg/ml) and EtOH (5 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Description: Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle
Handling: Teratogen!
USAGE: For Research Use Only! Not For Use in Humans.
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GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45
Fax 0032 16 50 90 45
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San Jose, CA 95123
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Related Genes :
[] Smoothened (Fragment)
Bibliography :
[29662325] Sonic hedgehog signaling in spinal cord contributes to morphine-induced hyperalgesia and tolerance through upregulating brain-derived neurotrophic factor expression.
[29658573] Hedgehog signaling regulates the expression levels of inflammatory mediators in cigarette‑induced airway inflammation.
[29637395] The Effect of Pancreas Islet-Releasing Factors on the Direction of Embryonic Stem Cells Towards Pdx1 Expressing Cells.
[29618829] The genetic diversity within the 1.4 kb HLA-G 5' upstream regulatory region moderately impacts on cellular microenvironment responses.
[29607715] Hedgehog signaling contributes to bone cancer pain by regulating sensory neuron excitability in rats.
[29587133] The role of Hedgehog signaling in cementoblast differentiation.
[29573522] Liver kinase B1 suppresses growth of lung cancer cells through sonic hedgehog signaling pathway.
[29541219] Casticin inhibits the epithelial-mesenchymal transition in ovarian carcinoma via the hedgehog signaling pathway.
[29533111] Cyclopamine treatment disrupts extracellular matrix and alleviates solid stress to improve nanomedicine delivery for pancreatic cancer.
[29511614] The combined effect of overexpression and Shh manipulation on the function of insulin-producing cells derived from adipose-tissue stem cells.
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