GENTAUR Molecular Products.
Monoclonal Antibody, ELISA Kit, Polyclonal Antibody, Recombinant/Purified Protein.
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Index / Biovis / Cyclopamine / Product Detail : 1578-5 Cyclopamine
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#1578-5 Cyclopamine
| Price : | 262 | EUR |
| 297 | USD | |
| 203 | GBP | |
| 1101 | Zloty | |
| 35069 | JPY | |
| 2021 | NOK | |
| 2165 | SEK | |
| 296 | CHF |
Product name : Cyclopamine
Catalog number : 1578-5
Quantity: 5 mg
Availability: Yes
Supplier name : Biovis
Data sheet: Ask more or other datasheet now !
More Details about
Alternate Name/Synonyms: 11-deoxojervine
Appearance: Off-white solid
Formulation: N/A
CAS Number: 4449-51-8
Molecular Formula: C₂₇H₄₁NO₂
Molecular Weight: 411.62
Purity: ≥99%
Solubility: DMSO (4 mg/ml) and EtOH (5 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Description: Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle
Handling: Teratogen!
USAGE: For Research Use Only! Not For Use in Humans.
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GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45
Fax 0032 16 50 90 45
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San Jose, CA 95123
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Related Genes :
[] Smoothened (Fragment)
Bibliography :
[28667508] Laser irradiation promotes the proliferation of mouse pre-osteoblast cell line MC3T3-E1 through hedgehog signaling pathway.
[28647274] Sonic hedgehog pathway suppression and reactivation accelerates differentiation of rat adipose-derived mesenchymal stromal cells toward insulin-producing cells.
[28633965] Phosphoproteome analysis reveals a critical role for hedgehog signalling in osteoblast morphological transitions.
[28624529] Cyclopamine sensitizes TRAIL-resistant gastric cancer cells to TRAIL-induced apoptosis via endoplasmic reticulum stress-mediated increase of death receptor 5 and survivin degradation.
[28607372] Enhanced derivation of human pluripotent stem cell-derived cortical glutamatergic neurons by a small molecule.
[28591579] Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.
[28535764] In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor.
[28521273] Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS.
[28512846] Melatonin influences the sonic hedgehog signaling pathway in porcine cumulus oocyte complexes.
[28477008] Combination therapy with micellarized cyclopamine and temozolomide attenuate glioblastoma growth through Gli1 down-regulation.
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