GENTAUR Molecular Products.
Monoclonal Antibody, ELISA Kit, Polyclonal Antibody, Recombinant/Purified Protein.
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Index / Biovis / GDC_0941 / Product Detail : 1623-1 GDC_0941
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Sep
25th
#1623-1 GDC_0941
| Price : | 430 | EUR |
| 488 | USD | |
| 333 | GBP | |
| 1806 | Zloty | |
| 57542 | JPY | |
| 3316 | NOK | |
| 3553 | SEK | |
| 486 | CHF |
Product name : GDC_0941
Catalog number : 1623-1
Quantity: 1 mg
Availability: Yes
Supplier name : Biovis
Data sheet: Ask more or other datasheet now !
More Details about
MOLECULAR WEIGHT: 513.64
CAS NUMBER: 957054-30-7
APPEARANCE: Solid
SOLUBILITY: DMSO
PURITY: >99%
STORAGE: Keep cool and dry, Store at -20°C
DESCRIPTION: GDC-0941 is a potent inhibitor of p110α and p110δ (IC50 = 3 nM). It selectively binds to PI3 K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3-K/Akt signaling pathway.
HANDLING: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
FOR RESEARCH USE ONLY! Not to be used in humans.
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Related Genes :
[Gpd1 Gdc-1 Gdc1 Kiaa4010] Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)
[SLC25A16 GDA GDC] Graves disease carrier protein (GDC) (Mitochondrial solute carrier protein homolog) (Solute carrier family 25 member 16)
[LTD GDC1 At1g50900 F8A12.12] Protein LHCP TRANSLOCATION DEFECT (Protein GRANA-DEFICIENT CHLOROPLAST 1)
[sulA sfiA b0958 JW0941] Cell division inhibitor SulA
[RAB11FIP2 KIAA0941] Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11)
[SLC25A16 GDA] Graves disease carrier protein (GDC) (Graves disease autoantigen) (GDA) (Mitochondrial solute carrier protein homolog) (Solute carrier family 25 member 16)
[Ccel_0941] D-psicose 3-epimerase (DPEase) (EC 5.1.3.30)
[gcvPA Thal_0941] Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC 1.4.4.2) (Glycine cleavage system P-protein subunit 1) (Glycine decarboxylase subunit 1) (Glycine dehydrogenase (aminomethyl-transferring) subunit 1)
[Slc25a16 Gda] Graves disease carrier protein homolog (GDC) (Mitochondrial solute carrier protein homolog) (Solute carrier family 25 member 16)
[cysG AFK69_16055] Siroheme synthase
[glmU AFK69_04400] Bifunctional protein GlmU
[murE AFK69_01775] UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.-) (EC 6.3.2.13) (Meso-A2pm-adding enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase)
[COI] Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Fragment)
[COI] Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Fragment)
[gcvPB BN2364_0941] Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC 1.4.4.2) (Glycine cleavage system P-protein subunit 2) (Glycine decarboxylase subunit 2) (Glycine dehydrogenase (aminomethyl-transferring) subunit 2)
[rlmN AFK69_03935] Dual-specificity RNA methyltransferase RlmN (EC 2.1.1.192) (23S rRNA (adenine(2503)-C(2))-methyltransferase) (23S rRNA m2A2503 methyltransferase) (Ribosomal RNA large subunit methyltransferase N) (tRNA (adenine(37)-C(2))-methyltransferase) (tRNA m2A37 methyltransferase)
[asd AFK69_04445] Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase)
[thiI AFK69_08635] tRNA sulfurtransferase (EC 2.8.1.4) (Sulfur carrier protein ThiS sulfurtransferase) (Thiamine biosynthesis protein ThiI) (tRNA 4-thiouridine synthase)
[hmp AFK69_03845] Flavohemoprotein (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase)
[arnA AFK69_17095] Bifunctional polymyxin resistance protein ArnA
[HA] Hemagglutinin (Fragment)
[eno AFK69_01640] Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)
[Pik3cb] Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta)
[hflB ftsH AFK69_12955] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[Pik3cd] Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
[serS AFK69_14270] Serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (Seryl-tRNA(Ser/Sec) synthetase)
[argD dapC AFK69_14055] Acetylornithine/succinyldiaminopimelate aminotransferase (ACOAT) (DapATase) (Succinyldiaminopimelate transferase) (EC 2.6.1.11) (EC 2.6.1.17)
[argD dapC AFK69_07525] Acetylornithine/succinyldiaminopimelate aminotransferase (ACOAT) (DapATase) (Succinyldiaminopimelate transferase) (EC 2.6.1.11) (EC 2.6.1.17)
[prs AFK69_09050] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase)
[pyrG AFK69_01635] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (UTP--ammonia ligase)
Bibliography :
[27565810] Phase Ia/Ib study of the pan-class I PI3K inhibitor pictilisib (GDC-0941) administered as a single agent in Japanese patients with solid tumors and in combination in Japanese patients with non-squamous non-small cell lung cancer.
[27529512] Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer.
[27527858] Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas.
[27489350] Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells.
[27465249] PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma.
[27421985] Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation.
[27281609] Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers.
[27225693] Therapeutic benefit of selective inhibition of p110α PI3-kinase in pancreatic neuroendocrine tumors.
[27196766] Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R.
[27117832] PI3K as a Potential Therapeutic Target in Thymic Epithelial Tumors.
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