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#1759-25 Gemcitabine Hydrochloride
Product name : Gemcitabine Hydrochloride
Catalog number : 1759-25
Quantity: 25 mg
Supplier name : Biovis
Data sheet: Ask more or other datasheet now !
More Details about
Alternate Name/Synonyms: 2′,2′-difluoro-2′-deoxycytidine; Gamcitabine; Gemcitera; Gemsar; Gemzar; LY-188011
Peptide sequence: N/A
Appearance: White solid
CAS Number: 122111-03-9
Molecular Formula: C₉H₁₁F₂N₃O₄•HCl
Molecular Weight: 299.66
Purity: ≥98% by HPLC
Solubility: DMSO (10 mg/ml) or H2O (25 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Description: A nucleoside analog of deoxycytidine used in chemotherapy to treat various types of cancer. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
Handling: Protect from air and moisture
USAGE: For Research Use Only! Not For Use in Humans.
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[ABCB1 MDR1 PGY1] Multidrug resistance protein 1 (EC 188.8.131.52) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243)
 Liver carboxylesterase (EC 184.108.40.206) (Proline-beta-naphthylamidase) (Retinyl ester hydrolase) (REH)
[TYMS TS OK/SW-cl.29] Thymidylate synthase (TS) (TSase) (EC 220.127.116.11)
[RNR1 CRT7 RIR1 SDS12 YER070W] Ribonucleoside-diphosphate reductase large chain 1 (EC 18.104.22.168) (Ribonucleotide reductase R1 subunit 1) (Ribonucleotide reductase large subunit 1)
[DCK] Deoxycytidine kinase (dCK) (EC 22.214.171.124)
[SLC28A3 CNT3] Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (hCNT3)
[CDA CDD] Cytidine deaminase (EC 126.96.36.199) (Cytidine aminohydrolase)
[SLC29A1 ENT1] Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)
[RRM1 RR1] Ribonucleoside-diphosphate reductase large subunit (EC 188.8.131.52) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)
[CMPK1 CMK CMPK UCK UMK UMPK] UMP-CMP kinase (EC 184.108.40.206) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 220.127.116.11) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK)
[RELB] Transcription factor RelB (I-Rel)
[SLC29A2 DER12 ENT2 HNP36] Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)
[IER3 DIF2 IEX1 PRG1] Radiation-inducible immediate-early gene IEX-1 (Differentiation-dependent gene 2 protein) (Protein DIF-2) (Immediate early protein GLY96) (Immediate early response 3 protein) (PACAP-responsive gene 1 protein) (Protein PRG1)
[SLC28A1 CNT1] Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1)
[NUPR1 COM1] Nuclear protein 1 (Candidate of metastasis 1) (Nuclear transcriptional regulator protein 1) (Protein p8)
[ABCC10 MRP7 SIMRP7] Multidrug resistance-associated protein 7 (ATP-binding cassette sub-family C member 10)
[IER3 IEX1] Radiation-inducible immediate-early gene IEX-1 (Immediate early protein GLY96) (Immediate early response 3 protein)
 Genome polyprotein
[Slc28a3 Cnt3] Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (mCNT3)
[Slc28a3 Cnt3] Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (rCNT3)
[SLC28A3 CNT3] Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT)
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