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Index / Signosis 2011 / Human T Cell Receptor Signaling cDNA Plate Array / Product Detail : AP-0191 Human T Cell Receptor Signaling cDNA Plate Array
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#AP-0191 Human T Cell Receptor Signaling cDNA Plate Array

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  Price : 464   EUR
527   USD
360   GBP
1950   Zloty
62122   JPY
3580   NOK
3836   SEK
525   CHF

Product name : Human T Cell Receptor Signaling cDNA Plate Array

Catalog number : AP-0191

Quantity: 4

Availability: Yes

Supplier name : Signosis 2011

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More Details about

Human T Cell Receptor Signaling cDNA Plate Array

T-Cells are a subset of lymphocytes that play a key role in the immune response. T-Cell Receptor (TCR) is a complex of integral membrane proteins that participates in the activation of T-Cells in response to antigen. This activation involves subunits of the receptor complex as well as other membrane-associated molecules that couple the extracellular liganding event to downstream signaling pathways such as the increase of inositol phosphates, the elevation of intracellular calcium levels and protein phosphorylation. TCR activation promotes a number of signaling cascades that ultimately determine cell fate through regulating cytokine production, cell survival, proliferation, and differentiation. 
 

Signosis developed a plate-based array for profiling 20+ Human T Cell Receptor Signaling-regulated genes. By using this assay, researchers are able to screen up to three samples on a single microtiter plate to compare gene expression in three separate constructs side by side.
 

List of Applicable Genes

  1 2 3 4 5 6 7 8 9 10 11 12
A CD45 JNK PLCr CD45 JNK PLCr CD45 JNK PLCr CD45 JNK PLCr
B ELK JUN Raf1 ELK JUN Raf1 ELK JUN Raf1 ELK JUN Raf1
C B-actin LAT Ras B-actin LAT Ras B-actin LAT Ras B-actin LAT Ras
D GADS LCK SLP76 GADS LCK SLP76 GADS LCK SLP76 GADS LCK SLP76
E GRB2 NFAT SOS GRB2 NFAT SOS GRB2 NFAT SOS GRB2 NFAT SOS
F IL2 NFkB TCRz IL2 NFkB TCRz IL2 NFkB TCRz IL2 NFkB TCRz
G IP3R p38 Zap70 IP3R p38 Zap70 IP3R p38 Zap70 IP3R p38 Zap70
H ITK PKC-theta blank ITK PKC-theta blank ITK PKC-theta blank ITK PKC-theta blank
 

 

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