Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :11164392
Publication Date : //

Met-Ile-Phe-Leu derivatives: full and partial agonists of human neutrophil formylpeptide receptors.


The biological action of a series of Met-Ile-Phe-Leu analogues was analyzed on human neutrophils, to evaluate their ability to interact with formylpeptide receptors and to induce the related neutrophil responses. Three in vitro assays were carried out: receptor binding, chemotaxis and superoxide anion release. Our results demonstrate that formyl-Met-Ile-Phe-Leu derivatives act as more potent full agonists than formyl-Met-Leu-Phe, the tripeptide normally used as a model chemoattractant for the study of cell functions. On the other hand, the presence of N-ureidoisopropyl substituent in tetrapeptides imparts weak partial agonist properties. It has furthermore been demonstrated that the C-terminal methyl esterification or amination weakly influences the properties of tetrapeptide homologues. Finally, t-Boc-Met-Ile-Phe-Leu derivatives do not appear able to interact with formylpeptide receptors.

Authors : Dalpiaz A , Scatturin A , Vertuani G , Pecoraro R , Borea P A , Varani K , Traniello S , Spisani S ,

Related products :

Catalog number Product name Quantity
305-31891 Anti_AdipoR1 Human Polyclonal Antibody PPAR agonists are reported to increase expression of activated adiponectin. PPAR__ agonists also increase expression of adiponectin receptors (Ref.2). Such findi 100 UG
U1914m CLIA Formyl peptide receptor 2,Formylpeptide receptor-related sequence 2,Fpr2,Fpr-rs2,Lipoxin A4 receptor-like protein,Mouse,Mus musculus,N-formylpeptide receptor-like 2 96T
E1914m ELISA kit Formyl peptide receptor 2,Formylpeptide receptor-related sequence 2,Fpr2,Fpr-rs2,Lipoxin A4 receptor-like protein,Mouse,Mus musculus,N-formylpeptide receptor-like 2 96T
U1914m CLIA kit Formyl peptide receptor 2,Formylpeptide receptor-related sequence 2,Fpr2,Fpr-rs2,Lipoxin A4 receptor-like protein,Mouse,Mus musculus,N-formylpeptide receptor-like 2 96T
E1914m ELISA Formyl peptide receptor 2,Formylpeptide receptor-related sequence 2,Fpr2,Fpr-rs2,Lipoxin A4 receptor-like protein,Mouse,Mus musculus,N-formylpeptide receptor-like 2 96T
32-139 Clenbuterol belongs to the group of agonists. In livestock production clenbuterol improves the meat_fat ratio in fattened animals or accelerate the growth. Up to now agonists have not been authorized 0.1 mg
201NGA01_CN NGAL neutrophil gelatinase_associated lipocalin, human, full length, 13C,15N
201NGA01_C NGAL neutrophil gelatinase_associated lipocalin, human, full length, 13C
201NGA01 NGAL neutrophil gelatinase_associated lipocalin, human, full length 100ug
201NGA01 NGAL neutrophil gelatinase_associated lipocalin, human, full length 0.5mg
201NGA01 NGAL neutrophil gelatinase_associated lipocalin, human, full length 5x0.5mg
201NGA01_N NGAL neutrophil gelatinase_associated lipocalin, human, full length, 15N
201NGA01_H NGAL neutrophil gelatinase_associated lipocalin, human, full length, unlabelled
25-907 Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficien 0.05 mg
25-180 Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. T 0.05 mg
27-314 RBPSUH is a DNA binding protein that activates a full transcriptional response but only demonstrates partial anti-apoptotic activity. RTA-mediated redirection of RBPSUH activity from repression to act 0.05 mg
EIAAB26517 47 kDa autosomal chronic granulomatous disease protein,47 kDa neutrophil oxidase factor,Homo sapiens,Human,NCF1,NCF-1,NCF-47K,Neutrophil cytosol factor 1,Neutrophil NADPH oxidase factor 1,Nox organize
31-110 GRIA2 is one of the glutamate receptors, which are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The 0.1 mg
31-145 Receptors for the C-C chemokine family include CKR-I, CKR-2A, CKR-3, CKR-4, CKR- 5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration 0.1 mg
26-475 Receptors for the Fc fragment of IgG, or FCGRs, are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effe 0.05 mg
25-760 Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma me 0.05 mg
26-179 Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activatin 0.05 mg
30-087 The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize wit 0.1 mg
28-969 The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize wit 0.1 mg
31-087 CCR8 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur