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Pubmed ID :12710751
Publication Date : //

Quantification and localization of platelet-derived growth factor in gingiva of periodontitis patients.


Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for cells of mesenchymal origin. Over-expression of PDGF-B can promote formation of inflammatory lesions in the lungs of transgenic mice. Moreover, continuous exposure to PDGF inhibits collagen production by osteoblastic cells. Thus, the expression of mitogenic factors in an inflammatory context may limit the differentiated function of cells, and thereby limit repair following periodontal attachment and bone loss. The goals of the present study were to test whether PDGF is present at increased levels in inflamed gingiva and to localize its expression in gingival biopsies from individuals with chronic periodontitis.

Authors : Pinheiro Maria Leticia B , Feres-Filho Eduardo J , Graves Dana T , Takiya Christina M , Elsas Maria Ignez G , Elsas Pedro Paulo , Luz Ricardo A ,

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