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Pubmed ID :12792516
Publication Date : //

Serine proteinase inhibitor-9, an endogenous blocker of granzyme B/perforin lytic pathway, is hyperexpressed during acute rejection of renal allografts.


Serine proteinase inhibitor (PI)-9 with a reactive center P1 (Glu)-P1' is a natural antagonist of granzyme B and is expressed in high levels in cytotoxic T lymphocytes (CTL). In view of the role of CTL in acute rejection, we explored the hypothesis that PI-9 would be hyperexpressed during acute rejection. Because PI-9 can protect CTL from its own fatal arsenal and potentially enhance the vitality of CTL, we examined whether PI-9 levels correlate with the severity of rejection as well as predict subsequent graft function.

Authors : Muthukumar Thangamani , Ding Ruchuang , Dadhania Darshana , Medeiros Mara , Li Baogui , Sharma Vijay K , Hartono Choli , Serur David , Seshan Surya V , Volk Hans-Dieter , Reinke Petra , Kapur Sandip , Suthanthiran Manikkam ,

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