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Pubmed ID :12847691
Publication Date : //

Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts.


Scleroderma is characterized by excessive synthesis and accumulation of matrix proteins in lesional tissues. Transforming growth factor beta (TGFbeta) plays a central role in the pathogenesis of fibrosis by inducing and sustaining activation of fibroblasts; however, the underlying mechanisms are poorly understood. We undertook this study to examine the expression and function of SMADs, recently characterized intracellular effectors of TGFbeta signaling, in scleroderma fibroblasts.

Authors : Mori Yasuji , Chen Shu-Jen , Varga John ,

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