Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Publication Date : //
Over 90% of human pancreatic cancers harbor an activating point mutation in the K-ras gene at codon 12. However, it is not clear whether all downstream K-ras are activated and which downstream contributes to the cell survival and proliferation of pancreatic cancer cells. MEK kinase 1 (MEKK1)-c-Jun N-terminal kinase (JNK)-c-Jun pathway has an important role in cell proliferation, survival and apoptosis in various cells. We previously demonstrated that the dominant negative form of MEKK1 (DN-MEKK) inhibits the survival of human pancreatic cancer cell lines. In this study we investigated whether JNK-c-Jun, the downstream pathway of DN-MEKK, affects the survival of human pancreatic cancer cell lines. Colony formation assays indicated that c-Jun failed to inhibit the survival of pancreatic cancer cells, whereas c-Jun remarkably inhibited the cell survival of non-pancreatic cancer cells. Reporter gene assays using Gal4-c-Jun and gel retardation assays indicated that c-Jun functions were activated in growing pancreatic cancer cells. These results revealed that c-Jun activation does not prevent the cell survival of pancreatic cancer cells in contrast to non-pancreatic cancer cells. It appears that MEKK1-JNK-c-Jun pathway fails to act as a negative regulator for the cell survival of pancreatic cancer cells. Greater understanding of these mechanisms may be helpful in the treatment of pancreatic cancer.
Authors : Okutomi Yoshiyuki , Shino Yuji , Komoda Fumitake , Hirano Tatsuya , Ishihara Takeshi , Yamaguchi Taketo , Saisho Hiromitsu , Shirasawa Hiroshi ,
Related products :
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
firstname.lastname@example.org | Gentaur | Gentaur
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Finland Helsset +358942419041
Magyarország Budapest +3619980547
US New York+17185132983
WP2256: Integrated Pancreatic Cancer Pathway
WP2367: Private Pancreatic Cancer
WP2377: Integrated Pancreatic Cancer Pathway
WP1019: FAS pathway and Stress induction of HSP regulation
WP1043: Calcium Regulation in the Cardiac Cell
WP1062: Regulation of Actin Cytoskeleton
WP1111: Prostaglandin Synthesis and Regulation
WP1138: FAS pathway and Stress induction of HSP regulation
WP1159: Calcium Regulation in the Cardiac Cell
WP1178: Regulation of Actin Cytoskeleton
WP1365: Calcium Regulation in the Cardiac Cell
WP1380: Regulation of Actin Cytoskeleton
WP1425: BMP signalling and regulation
WP1449: Regulation of toll-like receptor signaling pathway
WP1530: miRNA regulation of DNA Damage Response
WP1578: BMP signalling and regulation
WP1589: Folate-Alcohol and Cancer Pathway
WP1603: Nicotine Activity on Chromaffin Cells
WP1820: Gap junction trafficking and regulation
WP1872: Neurotransmitter uptake and Metabolism In Glial Cells
WP1896: Regulation of Apoptosis
WP1897: Regulation of beta-cell development
WP1898: Regulation of DNA replication
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1900: Regulation of mitotic cell cycle
Related Genes :
 DDX39 promotes hepatocellular carcinoma growth and metastasis through activating Wnt/β-catenin pathway.
 Neutrophils infiltrating pancreatic ductal adenocarcinoma indicate higher malignancy and worse prognosis.
 ROS mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose metabolism in pancreatic cancer.
 ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway.
 Puerarin Induces Hepatocellular Carcinoma Cell Apoptosis Modulated by MAPK Signaling Pathways in a Dose-dependent Manner.
 DKK3 Overexpression Increases the Malignant Properties of Head and Neck Squamous Cell Carcinoma Cells.
 Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2.
 Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer.
 Acquired Resistance with Epigenetic Alterations Under Long-Term Antiangiogenic Therapy for Hepatocellular Carcinoma.
 Elevated interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) is a poor prognostic marker in pancreatic ductal adenocarcinoma.
Enter catalog number :