Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :15613615
Publication Date : //

Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion.


Genomic microarray analysis of genes specifically expressed in a pure cell isolate from a heterocellular organ identified the likely K efflux channel associated with the gastric H-K-ATPase. The function of this channel is to supply K to the luminal surface of the pump to allow H for K exchange. KCNQ1-KCNE2 was the most highly expressed and significantly enriched member of the large variety of K channels expressed in the gastric epithelium. The function of this K channel in acid secretion was then shown by inhibition of secretion in isolated gastric glands with specific KCNQ inhibitors and by colocalization of the channel with the H-K-ATPase in the secretory canaliculus of the parietal cell. KCNQ1-KCNE2 appears to be the K efflux channel that is essential for gastric acid secretion.

Authors : Lambrecht Nils W G , Yakubov Iskandar , Scott David , Sachs George ,

Related products :

Catalog number Product name Quantity
orb60651 Esomeprazole magnesium Esomeprazole magnesium(Nexium) is a proton pump inhibitor to reduce gastric acid secretion. For research use only. 10 mg
orb82823 EGF protein EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved 1 mg
AS11 1830 Antibody: Auxin efflux carrier component, Immunogen: recombinant part of Populus TrichocarpaAuxin efflux carrier component protein B9H7N4, Host: rabbit, polyclonal, Confirmed reactivity: to be determi 100
18-003-42620 Potassium channel subfamily K member 3 - Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+) channel 1; Two pore potassium channel KT3.1 Polyclonal 0.1 mg Protein A
18-003-43175 Potassium channel subfamily K member 5 - Acid-sensitive potassium channel protein TASK-2; TWIK-related acid-sensitive K(+) channel 2 Polyclonal 0.05 mg Aff Pur
18-003-42628 Amiloride-sensitive cation channel 3 - Acid-sensing ion channel 3; ASIC3; hASIC3; Testis sodium channel 1; hTNaC1 Polyclonal 0.1 mg Protein A
EIAAB36978 Amino acid transporter A3,ATA3,Homo sapiens,Human,Na(+)-coupled neutral amino acid transporter 4,NAT3,SLC38A4,SNAT4,Sodium-coupled neutral amino acid transporter 4,Solute carrier family 38 member 4,Sy
EIAAB36979 Amino acid transporter A3,Ata3,Na(+)-coupled neutral amino acid transporter 4,Rat,Rattus norvegicus,Slc38a4,Snat4,Sodium-coupled neutral amino acid transporter 4,Solute carrier family 38 member 4,Syst
EIAAB36986 Homo sapiens,Human,Na(+)-coupled neutral amino acid transporter 6,NAT1,NAT-1,N-system amino acid transporter 1,Probable sodium-coupled neutral amino acid transporter 6,SLC38A6,SNAT6,Solute carrier fam
EIAAB36980 Amino acid transporter A3,Ata3,Mouse,Mus musculus,Na(+)-coupled neutral amino acid transporter 4,Nat3,Slc38a4,Snat4,Sodium-coupled neutral amino acid transporter 4,Solute carrier family 38 member 4,Sy
EIAAB36976 mNAT,Mouse,Mus musculus,Na(+)-coupled neutral amino acid transporter 3,N-system amino acid transporter 1,Slc38a3,Sn1,Snat3,Sodium-coupled neutral amino acid transporter 3,Solute carrier family 38 memb
EIAAB36977 G17,Homo sapiens,Human,Na(+)-coupled neutral amino acid transporter 3,NAT1,N-system amino acid transporter 1,SLC38A3,SN1,SNAT3,Sodium-coupled neutral amino acid transporter 3,Solute carrier family 38
EIAAB36985 Na(+)-coupled neutral amino acid transporter 6,Nat1,NAT-1,N-system amino acid transporter 1,Probable sodium-coupled neutral amino acid transporter 6,Rat,Rattus norvegicus,Slc38a6,Snat6,Solute carrier
EIAAB36975 Na(+)-coupled neutral amino acid transporter 3,N-system amino acid transporter 1,Rat,Rattus norvegicus,Slc38a3,Snat3,Sodium-coupled neutral amino acid transporter 3,Solute carrier family 38 member 3,S
EIAAB28476 GPR120,GPR129,G-protein coupled receptor 120,G-protein coupled receptor 129,G-protein coupled receptor GT01,G-protein coupled receptor PGR4,Homo sapiens,Human,O3FAR1,Omega-3 fatty acid receptor 1,PGR4
EIAAB06989 ABCC7,ATP-binding cassette sub-family C member 7,cAMP-dependent chloride channel,CFTR,CFTR,Channel conductance-controlling ATPase,Cystic fibrosis transmembrane conductance regulator,Pig,Sus scrofa
EIAAB06991 ABCC7,ATP-binding cassette sub-family C member 7,Bos taurus,Bovine,cAMP-dependent chloride channel,CFTR,CFTR,Channel conductance-controlling ATPase,Cystic fibrosis transmembrane conductance regulator
EIAAB06993 ABCC7,ATP-binding cassette sub-family C member 7,cAMP-dependent chloride channel,CFTR,CFTR,Channel conductance-controlling ATPase,Cystic fibrosis transmembrane conductance regulator,Oryctolagus cunicu
EIAAB06992 Abcc7,ATP-binding cassette sub-family C member 7,cAMP-dependent chloride channel,CFTR,Cftr,Channel conductance-controlling ATPase,Cystic fibrosis transmembrane conductance regulator,Rat,Rattus norvegi
EIAAB06988 Abcc7,ATP-binding cassette sub-family C member 7,cAMP-dependent chloride channel,CFTR,Cftr,Channel conductance-controlling ATPase,Cystic fibrosis transmembrane conductance regulator,Mouse,Mus musculus
EIAAB06994 ABCC7,ATP-binding cassette sub-family C member 7,cAMP-dependent chloride channel,CFTR,CFTR,Channel conductance-controlling ATPase,Cystic fibrosis transmembrane conductance regulator,Homo sapiens,Human
orb41644 V ATPase C2 antibody Polyclonal Rabbit polyclonal to V ATPase C2. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracell 100
orb41647 V ATPase H antibody Polyclonal Rabbit polyclonal to V ATPase H. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellul 100
25-949 ATP4B belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glyc 0.05 mg
EIAAB05304 CADPS2,Calcium-dependent activator protein for secretion 2,Calcium-dependent secretion activator 2,CAPS2,CAPS-2,Homo sapiens,Human,KIAA1591


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur