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Pubmed ID :15825075
Publication Date : //

Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells.


Mice that have a truncated mutation of the common cytokine receptor gamma chain (CR gamma -/Y) are known to spontaneously develop colitis. To identify the pathologic elements responsible for triggering this localized inflammatory disease, we elucidated and characterized aberrant T cells and their enteropathogenic cytokines in CR gamma -/Y mice with colitis.

Authors : Kai Yasuyuki , Takahashi Ichiro , Ishikawa Hiromichi , Hiroi Takachika , Mizushima Tsunekazu , Matsuda Chu , Kishi Daisuke , Hamada Hiromasa , Tamagawa Hiroshi , Ito Toshinori , Yoshizaki Kazuyuki , Kishimoto Tadamitsu , Matsuda Hikaru , Kiyono Hiroshi ,

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