Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :15857288
Publication Date : //

Monoclonal antibodies targeting the epidermal growth factor receptor.


The epidermal growth factor receptor (EGFR, HER1) autocrine pathway contributes to a number of highly relevant processes in cancer development and progression, including cell proliferation, regulation of apoptotic cell death, angiogenesis and metastatic spread. The crucial role that EGFR plays in human cancers has led to an extensive search for selective inhibitors of its signaling pathway. The results of a large body of preclinical studies and clinical trials thus far conducted suggest that targeting the EGFR could bring a significant contribution to cancer therapy. A variety of different approaches are currently being used to target the EGFR. The most promising strategies in clinical development include monoclonal antibodies, to prevent ligand binding, and small molecules inhibitors of the tyrosine kinase enzymatic activity, that inhibit autophosphorylation and downstream intracellular signaling. Several blocking monoclonal antibodies against the EGFR have been developed. Among these, IMC-225 is a chimeric human-mouse monoclonal IgG1 antibody that has been the first anti-EGFR targeted therapy to enter clinical evaluation in cancer patients in Phase II and III studies, alone or in combination with conventional radiotherapy and chemotherapy. However, other antibodies against EGFR have demonstrated antitumor activity in several preclinical models of human cancer and are currently under investigation in the clinical setting, such as ICR62, ABX-EGF and EMD72000. This review will focus on all the preclinical data available on monoclonal antibodies engineered against the EGF receptor.

Authors : Bianco R , Daniele G , Ciardiello F , Tortora G ,

Related products :

Catalog number Product name Quantity
RAN-042 Mouse Anti Human Epidermal Growth Factor Receptor MONOCLONAL ANTIBODIES 5
18-461-10732 Cadherin EGF LAG seven-pass G-type receptor 3 - Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains 2; Epidermal growth factor-like 1 Polyclonal 0.05 ml
18-461-10733 Cadherin EGF LAG seven-pass G-type receptor 3 - Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains 2; Epidermal growth factor-like 1 Polyclonal 0.05 ml
18-461-10735 Cadherin EGF LAG seven-pass G-type receptor 3 - Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains 2; Epidermal growth factor-like 1 Polyclonal 0.05 ml
18-461-10440 Cadherin EGF LAG seven-pass G-type receptor 3 - Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains 2; Epidermal growth factor-like 1 Polyclonal 0.05 ml
18-461-10703 Cadherin EGF LAG seven-pass G-type receptor 3 - Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains 2; Epidermal growth factor-like 1 Polyclonal 0.05 ml
A 1016AG.2 Epidermal Growth Factor-Receptor (EGF-R) antigen: human Epidermal Growth Factor-Receptor 100
A 1016AG.1 Epidermal Growth Factor-Receptor (EGF-R) antigen: human Epidermal Growth Factor-Receptor 10
20-321-175098 EPIDERMAL GROWTH FACTOR - MONOCLONAL ANTIBODY TO HUMAN RECOMBINANT EPIDERMAL GROWTH FACTOR Monoclonal 0.5 mg
20-321-175097 EPIDERMAL GROWTH FACTOR - MONOCLONAL ANTIBODY TO HUMAN RECOMBINANT EPIDERMAL GROWTH FACTOR Monoclonal 0.1 mg
29-763 EPS8L1 a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown.This gene 0.1 mg
20-663-48061 Epidermal Growth Factor - Mouse Anti Human Epidermal Growth Factor Monoclonal 1 mg
20-663-48061 Epidermal Growth Factor - Mouse Anti Human Epidermal Growth Factor Monoclonal 0.5 mg
20-783-70962 RAT ANTI HUMAN EGF RECEPTOR - EPIDERMAL GROWTH FACTOR RECEPTOR; Monoclonal 0.2 mg
20-783-70958 RAT ANTI HUMAN EGF RECEPTOR - EPIDERMAL GROWTH FACTOR RECEPTOR; Monoclonal 0.2 mg
20-783-70955 RAT ANTI HUMAN EGF RECEPTOR - EPIDERMAL GROWTH FACTOR RECEPTOR; Monoclonal 0.2 mg
20-783-70957 RAT ANTI HUMAN EGF RECEPTOR RPE - EPIDERMAL GROWTH FACTOR RECEPTOR; Monoclonal 100 TESTS
20-783-71656 SHEEP ANTI HUMAN EGF RECEPTOR - EPIDERMAL GROWTH FACTOR RECEPTOR; Monoclonal 0.5 mg
20-783-72122 MOUSE ANTI HUMAN EGF RECEPTOR - EPIDERMAL GROWTH FACTOR RECEPTOR; Monoclonal 2 ml
20-783-71657 SHEEP ANTI HUMAN EGF RECEPTOR - EPIDERMAL GROWTH FACTOR RECEPTOR; Monoclonal 0.5 mg
20-783-70956 RAT ANTI HUMAN EGF RECEPTOR FITC - EPIDERMAL GROWTH FACTOR RECEPTOR; Monoclonal 0.1 mg
20-783-72123 MOUSE ANTI HUMAN EGF RECEPTOR FITC - EPIDERMAL GROWTH FACTOR RECEPTOR; Monoclonal 1 ml
18-003-43740 Epidermal growth factor receptor kinase substrate 8-like protein 1 - Epidermal growth factor receptor pathway substrate 8-related protein 1; EPS8-like protein 1 Polyclonal 0.1 mg Protein A
MO-C40044H Epidermal Growth Factor (EGF), Monoclonal Antibodies to Human Cytokines and Growth Factors, Host:Mouse, Isotype: IgG1,k, Clone: S-21, Aff. pur. 0.5 mg
MO-C40044D Epidermal Growth Factor (EGF), Monoclonal Antibodies to Human Cytokines and Growth Factors, Host:Mouse, Isotype: IgG1,k, Clone: S-21, Aff. pur. 0.5 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur