Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :17599962
Publication Date : //

Sensitivity of coherent oscillations in rat hippocampus to AC electric fields.

The sensitivity of brain tissue to weak extracellular electric fields is important in assessing potential public health risks of extremely low frequency (ELF) fields, and potential roles of endogenous fields in brain function. Here we determine the effect of applied electric fields on membrane potentials and coherent network oscillations. Applied DC electric fields change transmembrane potentials in CA3 pyramidal cell somata by 0.18 mV per V m(-1) applied. AC sinusoidal electric fields have smaller effects on transmembrane potentials: sensitivity drops as an exponential decay function of frequency. At 50 and 60 Hz it is approximately 0.4 that for DC fields. Effects of fields of < or = 16 V m(-1) peak-to-peak (p-p) did not outlast application. Kainic acid (100 nm) induced coherent network oscillations in the beta and gamma bands (15-100 Hz). Applied fields of > or = 6 V m(-1) p-p (2.1 V m(-1) r.m.s.) shifted the gamma peak in the power spectrum to centre on the applied field frequency or a subharmonic. Statistically significant effects on the timing of pyramidal cell firing within the oscillation appeared at distinct thresholds: at 50 Hz, 1 V m(-1) p-p (354 mV m(-1) r.m.s.) had statistically significant effects in 71% of slices, and 0.5 V m(-1) p-p (177 mV m(-1) r.m.s.) in 20%. These threshold fields are consistent with current environmental guidelines. They correspond to changes in somatic potential of approximately 70 microV, below membrane potential noise levels for neurons, demonstrating the emergent properties of neuronal networks can be more sensitive than measurable effects in single neurons.

Authors : Deans Jacqueline K , Powell Andrew D , Jefferys John G R ,

Related products :

Catalog number Product name Quantity
MB-X0812D Neuron Culture Set _ Hippocampus(Rat) Primary nerve cells derived from rat hippocampus provided with medium and dissociation solutions. System provides highly viable, fully elongated neurons in cultu kit
MB-X0813D Neuron Culture Set _ Hippocampus(Mouse) Primary nerve cells derived from mouse hippocampus provided with medium and dissociation solutions. System provides highly viable, fully elongated neurons in c kit
F01383 Fields Stain A 25 G
RRSK25-500 Fields Stain Kit 500 Test
RRSK25-100 Fields Stain Kit 100 Test
RRSK25-200 Fields Stain Kit 200 Test
F01385 Fields Stain B 25 G
RRBD2577-U Fields Stain B Powder 10gm
RRSP41-D Fields Stain - Solution A 500ml
RRSP51-D Fields Stain - Solution B 500ml
RRSP51-C Fields Stain - Solution B 250ml
RRSP41-C Fields Stain - Solution A 250ml
RRSP51-B Fields Stain - Solution B 100ml
RRSP41-B Fields Stain - Solution A 100ml
RRSP51-A Fields Stain - Solution B 50ml
RRSP41-A Fields Stain - Solution A 50ml
RRBD2566-W Fields Stain A Powder 25gm
RRSP51-F Fields Stain - Solution B 2,5L
RRBD2566-X Fields Stain A Powder 100gm
RRBD2577-X Fields Stain B Powder 100gm
RRSP41-F Fields Stain - Solution A 2,5L
RRBD2566-U Fields Stain A Powder 10gm
RRSP41-G Fields Stain - Solution A 5L
RRSP51-G Fields Stain - Solution B 5L
RRBD2566-Y Fields Stain A Powder 1Kg


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur

Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017


france@gentaur.com | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur