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Pubmed ID :19445702
Publication Date : //

Characterization of the prohormone complement in cattle using genomic libraries and cleavage prediction approaches.


Neuropeptides are cell to cell signalling molecules that regulate many critical biological processes including development, growth and reproduction. These peptides result from the complex processing of prohormone proteins, making their characterization both challenging and resource demanding. In fact, only 42 neuropeptide genes have been empirically confirmed in cattle. Neuropeptide research using high-throughput technologies such as microarray and mass spectrometry require accurate annotation of prohormone genes and products. However, the annotation and associated prediction efforts, when based solely on sequence homology to species with known neuropeptides, can be problematic.

Authors : Southey Bruce R , Rodriguez-Zas Sandra L , Sweedler Jonathan V ,

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