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Pubmed ID :21998155
Publication Date : //

Protein stability: a single recorded mutation aids in predicting the effects of other mutations in the same amino acid site.


Accurate prediction of protein stability is important for understanding the molecular underpinnings of diseases and for the design of new proteins. We introduce a novel approach for the prediction of changes in protein stability that arise from a single-site amino acid substitution; the approach uses available data on mutations occurring in the same position and in other positions. Our algorithm, named Pro-Maya (Protein Mutant stAbilitY Analyzer), combines a collaborative filtering baseline model, Random Forests regression and a diverse set of features. Pro-Maya predicts the stability free energy difference of mutant versus wild type, denoted as ΔΔG.

Authors : Wainreb Gilad , Wolf Lior , Ashkenazy Haim , Dehouck Yves , Ben-Tal Nir ,

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