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Pubmed ID :22513294
Publication Date : //

Circulating microRNAs in serum of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas.


Novel biomarkers for pancreatic ductal adenocarcinoma (PDAC) are urgently needed because of its poor prognosis. We have previously established an animal model for human PDAC using transgenic rats in which expression of a human K-ras(G12V) oncogene is regulated by the Cre/lox system. Using this model, we searched for candidate circulating microRNAs (miRNAs) for use as novel clinical diagnostic biomarkers for PDAC.

Authors : Yabushita Setsuko , Fukamachi Katsumi , Tanaka Hajime , Sumida Kayo , Deguchi Yoshihito , Sukata Tokuo , Kawamura Satoshi , Uwagawa Satoshi , Suzui Masumi , Tsuda Hiroyuki ,

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