Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :22669316
Publication Date : //

Molecular epidemiological study of hepatitis B virus in blood donors from five Chinese blood centers.


Although the genetic variability of hepatitis B virus (HBV) in HBV-infected patients has been extensively studied, reports on genotypes, subtypes and mutations in the S region of HBV strains from Chinese blood donors are limited. In this study, 245 blood samples from HBsAg-positive blood donors were collected from five geographically diverse blood centers in China. The S region of HBV was amplified, and the HBV genotype and subtype were determined. The amino acid sequences of the S region were aligned, and mutations related to the failure of immunization and HBsAg detection were determined. Of the 245 samples, 228 (93 %) were genotyped successfully. We found that genotypes B, C, D and A accounted for 58.8 %, 21.9 %, 6.6 % and 3.95 % of the isolates, respectively. The distribution of HBV antigen subtypes was as follows: adw (67.6 %), adr (23.3 %) and ayw (8.7 %). Mutations were present in 39 (17.1 %) of 228 samples in the major hydrophilic region (MHR) of the S region. This study demonstrated that HBV genotype/subtype B/adw was the most frequent strain circulating in HBV-infected Chinese blood donors, followed by C/adr. The occurrence of MHR mutants in HBV-infected blood donors and the potential failure to detect some of them in collected units poses a threat to transfusion safety.

Authors : Liu Yu , Wang Jingxing , Huang Yi , Yang Tonghan , Guo Xiaoming , Li Julin , Wen Guoxin , Yun Zhongqiao , Zeng Peibin , He Miao , Xu Min , Liu Gui , Ke Ling , Wright David , Liu Jing , Nelson Kenrad , Shan Hua ,

Related products :

Catalog number Product name Quantity
BSCIM-123-V Human Whole Blood Special Project, 12 units whole blood sodium citrate, 2 units collected from donors A1rr, two units collected from donors Brr and 8 units collected from donors B R2r, not filtered, s 1 unit
2477 UNIPARENTAL DYSSOMIA STUDY, BLOOD 1
8301 RhD ZYGOSITY STUDY (PATERNAL), BLOOD 1
8266 COAGULATION FACTOR XII (GENETIC STUDY), BLOOD 1
B1090 Kracke Blood Culture Medium USE : For isolating organisms from the blood in bacterimias and for maintaining cultures isolated from blood. 5x500gm
B430 Blood Agar Base w_low pH(w_o Blood) USE : After addition of blood medium is used for isolation and cultivation of fastidious organisms. 5x500gm
B430 Blood Agar Base w_low pH(w_o Blood) USE After addition of blood medium is used for isolation and cultivation of fastidious organisms. Qty per Litre of Medium: 40
B1090 Kracke Blood Culture Medium USE For isolating organisms from the blood in bacterimias and for maintaining cultures isolated from blood. Qty per Litre of Medium: 75
991-50-P Whole Blood, Pooled Human Donors 5 mL
BI-120-D Cat Whole Blood, EDTA K3, individual donors 10 ml
BI-120-D Cat Whole Blood EDTA K3, Individual Donors 10ml
BI-120-D Cat Whole Blood, EDTA K3, individual donors 10ml
991-50-P Whole Blood, Pooled Human Donors 25 mL
991-50-P Whole Blood, Pooled Human Donors 1 mL
991-06-P Cord Blood, Pooled Human Donors 1 mL
991-06-P Cord Blood, Pooled Human Donors 10 mL
991-50-P WHOLE BLOOD, Human - Pooled Donors Liquid 25 mL
991-15P Menstrual Blood, Pooled Human Donors 5 mL
991-15P Menstrual Blood, Pooled Human Donors 2 mL
991-50-P WHOLE BLOOD, Human - Pooled Donors Liquid 5 mL
991-06-P Cord Blood, Pooled Human Donors 3 mL
991-50-P WHOLE BLOOD, Human - Pooled Donors Liquid 1 mL
991-15P Menstrual Blood, Pooled Human Donors 1 mL
B014 Blood Agar Base (Infusion Agar) w_o Blood USE : For isolation and cultivation of many fastidious pathogenic organisms after addition of blood. 5x500gm
B014 Blood Agar Base (Infusion Agar) w_o Blood USE For isolation and cultivation of many fastidious pathogenic organisms after addition of blood. Qty per Litre of Medium: 40


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur