Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :23192001
Publication Date : //

Generation and functional characterization of the anti-transferrin receptor single-chain antibody-GAL4 (TfRscFv-GAL4) fusion protein.


The development of vectors for cell-specific gene delivery is a major goal of gene therapeutic strategies. Transferrin receptor (TfR) is an endocytic receptor and identified as tumor relative specific due to its overexpression on most tumor cells or tissues, and TfR binds and intakes of transferrin-iron complex. We have previously generated an anti-TfR single-chain variable fragments of immunoglobulin (scFv) which were cloned from hybridoma cell line producing antibody against TfR linked with a 20 aa-long linker sequence (G4S)4. In the present study, the anti-TfR single-chain antibody (TfRscFv) was fused to DNA-binding domain of the yeast transcription factor GAL4. The recombinant fusion protein, designated as TfRscFv-GAL4, is expected to mediate the entry of DNA-protein complex into targeted tumor cells.

Authors : Ye Qing , Hu Heyu , Wang Zhihua , Lu Tong , Hu Zhiquan , Zeng Xing , Zhang Shu , Liu Jing , Lei Ping , Wang Cong-Yi , Ye Zhangqun , Shen Guanxin ,

Related products :

Catalog number Product name Quantity
PR-718 GAL4-VP16 Positive regulator of galactose inducible genes, GAL4(1-147) fused toVP16(411-490), herpes simplex virus virion transactivating protein]human, recombinant, E. coli 10
PR-718 GAL4-VP16His Positive regulator of galactose inducible genes, GAL4(1-147) fused toVP16(411-490), herpes simplex virus virion transactivating protein] human, recombinant, E. coli 10
PR-718 Proteins: GAL4-VP16His Positive regulator of galactose inducible genes, GAL4(1-147) fused toVP16(411-490)herpes simplex virus virion transactivating protein]human, recombinant, E. coli 10
PR-717 GAL4-AH Positive regulator of galactose inducible genes, GAL4(1-147) fused to an alpha-Helixhuman, recombinant, E. coli 10
PR-717 Proteins: GAL4-AH Positive regulator of galactose inducible genes, GAL4(1-147) fused to an alpha-Helixhuman, recombinant, E. coli 10
PR-717 GAL4-AH Positive regulator of galactose inducible genes, GAL4(1-147) fused to an alpha-Helix human, recombinant, E. coli 10
DL-GAL4-Mu Mouse Galectin 4 (GAL4) ELISA Kit 96T
DL-GAL4-Rb Rabbit Galectin 4 (GAL4) ELISA Kit 96T
DL-GAL4-Hu Human Galectin 4 (GAL4) ELISA Kit 96T
orb81435 Single Chain Cardiac Troponin I-C 2nd generation protein Recombinant Single Chain Cardiac Troponin I-C 2nd generation produced in E.coli is a single, non-glycosylated, polypeptide chain.The scIC2 is p 2
DL-GAL4-Ra Rat Galectin 4 (GAL4) ELISA Kit 96T
PR-719 GAL4-E1A Positive regulator of galactose inducible genes, GAL4(1-147) fused toE1A(121-223), Ubiquitin-like 1 activating enzyme E1A (SUMO-1 activating enzymehuman, recombinant, E. coli 4
PR-719 Proteins: GAL4-E1AHis Positive regulator of galactose inducible genes, GAL4(1-147) fused toE1A(121-223), Ubiquitin-like 1 activating enzyme E1A (SUMO-1 activating enzymehuman, recombinant, E. coli 4
PR-719 GAL4-E1AHis Positive regulator of galactose inducible genes, GAL4(1-147) fused toE1A(121-223), Ubiquitin-like 1 activating enzyme E1A (SUMO-1 activating enzyme human, recombinant, E. coli 4
20-272-191051 GAL4 - Mouse monoclonal [3G152] to GAL4 Monoclonal 0.1 mg
DL-GAL4-Rb GAL4 ELISA kit 96T
DL-GAL4-Ra GAL4 ELISA kit 96T
DL-GAL4-Mu GAL4 ELISA kit 96T
DL-GAL4-Hu GAL4 ELISA kit 96T
20-272-191279 GAL4 - Mouse monoclonal [5C8] to GAL4 Monoclonal 0.05 mg
YF-MA13985 anti-GAL4 (1E8) 100 ug
YF-PA24080 anti-GAL4 50 ul
orb81435 Single Chain Cardiac Troponin I-C 2nd generation protein Proteins 2
E02G0059 Rat anti-Galectin 4 Elisa Kit (GAL4) 96 Tests/kit
26-047 TFR2,a member of the transferrin receptor-like family,is a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimeriza 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur