Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :23306200
Publication Date : //

Ceruloplasmin is an endogenous inhibitor of myeloperoxidase.


Myeloperoxidase is a neutrophil enzyme that promotes oxidative stress in numerous inflammatory pathologies. It uses hydrogen peroxide to catalyze the production of strong oxidants including chlorine bleach and free radicals. A physiological defense against the inappropriate action of this enzyme has yet to be identified. We found that myeloperoxidase oxidized 75% of the ascorbate in plasma from ceruloplasmin knock-out mice, but there was no significant loss in plasma from wild type animals. When myeloperoxidase was added to human plasma it became bound to other proteins and was reversibly inhibited. Ceruloplasmin was the predominant protein associated with myeloperoxidase. When the purified proteins were mixed, they became strongly but reversibly associated. Ceruloplasmin was a potent inhibitor of purified myeloperoxidase, inhibiting production of hypochlorous acid by 50% at 25 nm. Ceruloplasmin rapidly reduced Compound I, the Fe(V) redox intermediate of myeloperoxidase, to Compound II, which has Fe(IV) in its heme prosthetic groups. It also prevented the fast reduction of Compound II by tyrosine. In the presence of chloride and hydrogen peroxide, ceruloplasmin converted myeloperoxidase to Compound II and slowed its conversion back to the ferric enzyme. Collectively, our results indicate that ceruloplasmin inhibits myeloperoxidase by reducing Compound I and then trapping the enzyme as inactive Compound II. We propose that ceruloplasmin should provide a protective shield against inadvertent oxidant production by myeloperoxidase during inflammation.

Authors : Chapman Anna L P , Mocatta Tessa J , Shiva Sruti , Seidel Antonia , Chen Brian , Khalilova Irada , Paumann-Page Martina E , Jameson Guy N L , Winterbourn Christine C , Kettle Anthony J ,

Related products :

Catalog number Product name Quantity
15-288-22348F Latexin - Endogenous carboxypeptidase inhibitor; ECI; Tissue carboxypeptidase inhibitor; TCI; MUM Polyclonal 0.1 mg
15-288-22348F Latexin - Endogenous carboxypeptidase inhibitor; ECI; Tissue carboxypeptidase inhibitor; TCI; MUM Polyclonal 0.05 mg
10-288-22348F Latexin - Endogenous carboxypeptidase inhibitor; ECI; Tissue carboxypeptidase inhibitor; TCI; MUM 0.05 mg
10-288-22348F Latexin - Endogenous carboxypeptidase inhibitor; ECI; Tissue carboxypeptidase inhibitor; TCI; MUM 0.1 mg
AXL3144 Levamisol, Alkaline Phosphatase Inhibitor (endogenous) 15 ml.
1977-500 Myeloperoxidase Inhibitor 4-Aminobenzoic hydrazide; MPO Inhibitor; 4-ABH 500 mg
1977-100 Myeloperoxidase Inhibitor 4-Aminobenzoic hydrazide; MPO Inhibitor; 4-ABH 100 mg
EIAAB14583 Emi2,Endogenous meiotic inhibitor 2,F-box only protein 43,Fbxo43,Mouse,Mus musculus
EIAAB14584 Emi2,Endogenous meiotic inhibitor 2,F-box only protein 43,Fbxo43,Rat,Rattus norvegicus
EIAAB12329 EBLN1,EBLN-1,Endogenous Borna-like N element-1,Endogenous Bornavirus-like nucleoprotein 1,Homo sapiens,Human
EIAAB14585 EMI2,Endogenous meiotic inhibitor 2,F-box only protein 43,FBXO43,Homo sapiens,Human
EIAAB12330 EBLN2,EBLN-2,Endogenous Borna-like N element-2,Endogenous Bornavirus-like nucleoprotein 2,GK006,Homo sapiens,Human
26-340 N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine.N-methylation of endogenous 0.05 mg
1977-100 Myeloperoxidase Inhibitor 100 mg
1977-500 Myeloperoxidase Inhibitor 500 mg
orb82123 Human Plasma Ceruloplasmin protein Ceruloplasmin is a purified protein_bioactive peptide. For research use only. 1 mg
orb21969 Goat Serum Against Human Ceruloplasmin Polyclonal Precipitating polyclonal goat antiserum to human alpha-2 ceruloplasmin. Alpha-2 ceruloplasmin is copper containing alpha-2 glycoprotein with a molecul 1 ml
LF-MA0159 anti-Ceruloplasmin (3B11), Mouse monoclonal to Ceruloplasmin, Isotype IgG1, Host Mouse 100 ul
1977-100 Myeloperoxidase Inhibitor; Appearance White to off-white solid 100 mg
1977-500 Myeloperoxidase Inhibitor; Appearance White to off-white solid 500 mg
orb82134 Human Myeloperoxidase protein Myeloperoxidase is a purified cardiac marker. For research use only. 100
orb81997 Human Myeloperoxidase protein Myeloperoxidase is a purified cardiac marker. For research use only. 1 mg
orb82174 Myeloperoxidase protein Myeloperoxidase is a purified cardiac marker. For research use only. 1 mg
orb81858 Human Myeloperoxidase protein Myeloperoxidase, Subform C is a purified cardiac marker. For research use only. 1 mg
3831BP-50 Myeloperoxidase (MPO) Blocking Peptide target: Myeloperoxidase (MPO) 50 μg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur