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Pubmed ID :23624001
Publication Date : //

Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model.


Sinusoidal obstruction syndrome (SOS) following oxaliplatin based chemotherapy can have a significant impact on post-operative outcome following resection of colorectal liver metastases. To date no relevant experimental models of oxaliplatin induced SOS have been described. The aim of this project was to establish a rodent model which could be utilised to investigate mechanisms underlying SOS to aid the development of therapeutic strategies.

Authors : Robinson S M , Mann J , Vasilaki A , Mathers J , Burt A D , Oakley F , White S A , Mann D A ,

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