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Pubmed ID :23789642
Publication Date : //

Decreased functional T lymphocyte-mediated cytokine responses in patients with chemotherapy-induced neutropenia.


The degree of immunosuppression in patients with haematological malignancies treated with chemotherapy is routinely measured as number of circulating cells (preferable neutrophils) in peripheral blood. A parallel decline in the number of T cells is expected, but a possible alteration in their functionality has been less well explored. The ability of T cells to secrete more than one cytokine simultaneously is known to indicate protective immunity. The aim of this study was to determine whether the function of circulating T cells is altered in patients with chemotherapy-induced neutropenia.

Authors : Öhrmalm L , Smedman C , Wong M , Broliden K , Tolfvenstam T , Norbeck O ,

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