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Pubmed ID :24231757
Publication Date : //

The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury.


One of the hallmarks of severe pneumonia and associated acute lung injury is neutrophil recruitment to the lung. Leptin is thought to be up-regulated in the lung following injury and to exert diverse effects on leukocytes, influencing both chemotaxis and survival. We hypothesized that pulmonary leptin contributes directly to the development of pulmonary neutrophilia during pneumonia and acute lung injury.

Authors : Ubags Niki D , Vernooy Juanita H , Burg Elianne , Hayes Catherine , Bement Jenna , Dilli Estee , Zabeau Lennart , Abraham Edward , Poch Katie R , Nick Jerry A , Dienz Oliver , Zuñiga Joaquin , Wargo Matthew J , Mizgerd Joseph P , Tavernier Jan , Rincón Mercedes , Poynter Matthew E , Wouters Emiel F M , Suratt Benjamin T ,

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