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Pubmed ID :24695353
Publication Date : //

Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity.


The reduction in mother-to-child transmission of HIV-1 by single-dose nevirapine given at birth onset is achieved at the expense of de novo HIV-1 resistance mutations. In the VITA1 study, single-dose carbamazepine accelerated nevirapine elimination, but the accompanying trend towards fewer de novo HIV-1 mutations was statistically non-significant.

Authors : Baranyai Dorothea , Muro Eva , Gödtel-Armbrust Ute , Schirmer Markus A , Kisanga Elton , Diczfalusy Ulf , Fillekes Quirine , Schuurman Rob , Burger David , Wojnowski Leszek ,

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