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Pubmed ID :25962509
Publication Date : //

Autoantigen cross-reactive environmental antigen can trigger multiple sclerosis-like disease.


Multiple sclerosis is generally considered an autoimmune disease resulting from interaction between predisposing genes and environmental factors, together allowing immunological self-tolerance to be compromised. The precise nature of the environmental inputs has been elusive, infectious agents having received considerable attention. A recent study generated an algorithm predicting naturally occurring T cell receptor (TCR) ligands from the proteome database. Taking the example of a multiple sclerosis patient-derived anti-myelin TCR, the study identified a number of stimulatory, cross-reactive peptide sequences from environmental and human antigens. Having previously generated a spontaneous multiple sclerosis (MS) model through expression of this TCR, we asked whether any of these could indeed function in vivo to trigger CNS disease by cross-reactive activation.

Authors : Reynolds Catherine J , Sim Malcolm J W , Quigley Kathryn J , Altmann Daniel M , Boyton Rosemary J ,

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