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Pubmed ID :26034127
Publication Date : 2015/10/02

Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.


Cross-talk and feedback between the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR cell signaling pathways is critical for tumor initiation, maintenance, and adaptive resistance to targeted therapy in a variety of solid tumors. Combined blockade of these pathways-horizontal blockade-is a promising therapeutic strategy; however, compounded dose-limiting toxicity of free small molecule inhibitor combinations is a significant barrier to its clinical application.

Authors : Dreaden Erik C , Kong Yi Wen , Morton Stephen W , Correa Santiago , Choi Ki Young , Shopsowitz Kevin E , Renggli Kasper , Drapkin Ronny , Yaffe Michael B , Hammond Paula T ,

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