Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :26196943
Publication Date : //

Protein phosphatase modulation of somatostatin receptor signaling in the mouse hippocampus.


Many inhibitory interneurones in the hippocampus release the neuropeptide somatostatin (SST) which inhibits neuronal excitability through Gi/Go-coupled receptors. To investigate the signaling pathways underlying the SST inhibition of neuronal excitability in the hippocampus, we performed perforated patch-clamp recordings from CA1 pyramidal neurones in acute brain slices from P14-P18 mice. Bath application of 1 μM SST reversibly reduces the frequency of action potential firing in response to depolarising current steps, and is associated with neuronal hyperpolarisation and a reduction in membrane resistance. This effect is mediated by potassium channels with KCNK-like pharmacology. In addition, in slices that have been cultured in vitro for seven days or more, SST also produces a hyperpolarisation independent reduction in action potential firing, which can be also observed in acute slices when the Ser/Thr protein phosphatases PP2A and PP4 are inhibited selectively with fostriecin. This hyperpolarisation independent effect of SST appears to be mediated by G-protein-activated inwardly rectifying K+ (GIRK) channels. Knockdown of protein phosphatase 5, by Cre recombinase mediated deletion of the floxed Ppp5c gene, blocks the hyperpolarisation independent effect of SST, and reduces the hyperpolarisation dependent effect in a manner consistent with increased SST receptor desensitisation. Thus, reversible protein phosphorylation provides a mechanism to enhance or diminish the inhibitory effect of SST, which could allow system level regulation of circuit excitability in the hippocampus.

Authors : Lucas Sarah J , Armstrong David L ,

Related products :

Catalog number Product name Quantity
25-987 Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and d 0.05 mg
EIAAB45124 Cbl-interacting protein p70,Mouse,Mus musculus,Sts1,STS-1,Suppressor of T-cell receptor signaling 1,T-cell ubiquitin ligand 2,TULA-2,Tyrosine-protein phosphatase STS1_TULA2,Ubash3b,Ubiquitin-associate
EIAAB33115 Ftp-1,Mouse,Mus musculus,Pancreatic carcinoma phosphatase 2,Pcp2,PCP-2,Protein-tyrosine phosphatase-lamda,Ptpf,PTPlambda,PTP-lambda,Ptpru,Receptor-type protein-tyrosine phosphatase psi,Receptor-type t
EIAAB33026 Mouse,Mus musculus,Protein tyrosine phosphatase DPZPTP,Protein tyrosine phosphatase PTP-BL,Protein-tyrosine phosphatase RIP,Ptp14,PTP36,Ptpn13,Tyrosine-protein phosphatase non-receptor type 13
EIAAB33094 Byp,HPTP beta-like tyrosine phosphatase,Mouse,Mus musculus,Protein-tyrosine phosphatase eta,Protein-tyrosine phosphatase receptor type J,Ptprj,Receptor-type tyrosine-protein phosphatase eta,R-PTP-eta,
29-544 GIPC1_GIPC, GIPC2, and GIPC3 are a family of central PDZ-domain proteins. GIPC2 might play important roles in human gastric cancer through modulation of growth factor signaling or cell adhesion. GIPC1 0.1 mg
EIAAB33092 Density-enhanced phosphatase 1,DEP1,DEP-1,Homo sapiens,HPTP eta,Human,Protein-tyrosine phosphatase eta,Protein-tyrosine phosphatase receptor type J,PTPRJ,Receptor-type tyrosine-protein phosphatase eta
EIAAB33053 70Z-SHP,Hcp,Hcph,Hematopoietic cell protein-tyrosine phosphatase,Mouse,Mus musculus,Protein-tyrosine phosphatase 1C,Ptp1C,PTP-1C,Ptpn6,PTPTY-42,SHP-1,SH-PTP1,Tyrosine-protein phosphatase non-receptor
EIAAB33048 Mouse,Mus musculus,Neural-specific protein-tyrosine phosphatase,Ptpn5,STEP,Striatum-enriched protein-tyrosine phosphatase,Tyrosine-protein phosphatase non-receptor type 5
EIAAB33109 Mouse,Mus musculus,Phosphotyrosine phosphatase 13,Protein-tyrosine-phosphatase SL,Ptp13,Ptprr,Receptor-type tyrosine-protein phosphatase R,R-PTP-R
26-436 SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably throu 0.05 mg
EIAAB45125 Cbl-interacting protein p70,Homo sapiens,Human,KIAA1959,STS1,STS-1,Suppressor of T-cell receptor signaling 1,T-cell ubiquitin ligand 2,TULA-2,Tyrosine-protein phosphatase STS1_TULA2,UBASH3B,Ubiquitin-
EIAAB33117 FMI,Homo sapiens,hPTP-J,Human,Pancreatic carcinoma phosphatase 2,PCP2,PCP-2,Protein-tyrosine phosphatase J,Protein-tyrosine phosphatase pi,Protein-tyrosine phosphatase receptor omicron,PTP pi,PTP-J,PT
EIAAB33112 LAR-PTP2,Leukocyte common antigen-related protein-tyrosine phosphatase 2,Ptprs,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase S,Receptor-type tyrosine-protein phosphatase sigma,R-PTP
EIAAB33118 Embryonic stem cell protein-tyrosine phosphatase,ES cell phosphatase,Esp,Mouse,Mus musculus,Ptprv,Receptor-type tyrosine-protein phosphatase V,R-PTP-V
EIAAB33015 Mouse,Mus musculus,Protein-tyrosine phosphatase 1B,Protein-tyrosine phosphatase HA2,PTP-1B,PTP-HA2,Ptpn1,Tyrosine-protein phosphatase non-receptor type 1
EIAAB33113 Mouse,mRPTPrho,Mus musculus,Ptprt,Receptor-type tyrosine-protein phosphatase rho,Receptor-type tyrosine-protein phosphatase T,RPTPmam4,RPTP-rho,R-PTP-T
E0954m ELISA LCA-related phosphatase,Lrp,Mouse,Mus musculus,Protein-tyrosine phosphatase alpha,Ptpa,Ptpra,PTPTY-28,Receptor-type tyrosine-protein phosphatase alpha,R-PTP-alpha 96T
U0954m CLIA LCA-related phosphatase,Lrp,Mouse,Mus musculus,Protein-tyrosine phosphatase alpha,Ptpa,Ptpra,PTPTY-28,Receptor-type tyrosine-protein phosphatase alpha,R-PTP-alpha 96T
E0954m ELISA kit LCA-related phosphatase,Lrp,Mouse,Mus musculus,Protein-tyrosine phosphatase alpha,Ptpa,Ptpra,PTPTY-28,Receptor-type tyrosine-protein phosphatase alpha,R-PTP-alpha 96T
MB-X0813D Neuron Culture Set _ Hippocampus(Mouse) Primary nerve cells derived from mouse hippocampus provided with medium and dissociation solutions. System provides highly viable, fully elongated neurons in c kit
EIAAB33030 Fetal liver phosphatase 1,Flp1,FLP-1,Mouse,Mus musculus,Ptpk1,PTP-K1,Ptpn18,Tyrosine-protein phosphatase non-receptor type 18
EIAAB33119 Embryonic stem cell protein-tyrosine phosphatase,ES cell phosphatase,Esp,Osteotesticular protein-tyrosine phosphatase,OST-PTP,Ptprv,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase V,R
EIAAB33077 Mouse,Mus musculus,Protein-tyrosine phosphatase beta,Ptprb,Receptor-type tyrosine-protein phosphatase beta,R-PTP-beta,Vascular endothelial protein tyrosine phosphatase,VE-PTP
15-288-21475 Receptor-type tyrosine-protein phosphatase eta - EC 3.1.3.48; Protein-tyrosine phosphatase eta; R-PTP-eta; HPTP eta; Protein-tyrosine phosphatase receptor type J; Density-enhanced phosphatase 1; DEP-1 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur