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Pubmed ID :26320498
Publication Date : //

Impact of RGD Peptide Tethering to IL24/mda-7 (Melanoma Differentiation Associated Gene-7) on Apoptosis Induction in Hepatocellular Carcinoma Cells.


Melanoma differentiation-associated gene-7 (MDA-7)/interleukin-24 (IL-24), a unique tumor suppressor gene, has killing activity in a broad spectrum of cancer cells. Herein, plasmids producing mda-7 proteins fused to different RGD peptides (full RGD4C and shortened RGD, tRGD) were evaluated for apoptosis induction with a hepatocellular carcinoma cell line, Hep-G2. The study aim was to improve the apoptosis potency of mda-7 by tethering to RGD peptides.

Authors : Bina Samaneh , Shenavar Fatemeh , Khodadad Mahboobeh , Haghshenas Mohammad Reza , Mortazavi Mojtaba , Fattahi Mohammad-Reza , Erfani Nasrollah , Hosseini Seyed Younes ,

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