Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :26477945
Publication Date : //

Accumulation of reactivity to MBP sensitizes TRAIL mediated oligodendrocyte apoptosis in adult sub cortical white matter in a model for human multiple sclerosis.


Reactivity to myelin associated proteins is the hallmark of human multiple sclerosis (M.S) and its experimental counterparts. However, the nature of such reactivity has not been described fully. Herein, we report that myelin basic protein (MBP) reactivity accumulates in a rat model for M.S. over a period of time and sensitizes TRAIL mediated progressive oligodendrocyte apoptosis. We used active immunization by Myelin Oligodendrocyte Glycoprotein (MOG, 50 μg) to study chronic remitting relapsing encephalomyelitis in rats. A time point analysis of the progressive disease revealed cumulative accumulation of anti myelin basic protein antibodies during the disease progression with minimal change in the anti-MOG antibodies. Increased reactivity to MBP was studied to sensitize TNF related apoptosis-inducing ligand (TRAIL) and other proinflammatory cytokines in a cumulative fashion leading to the Caspase dependent apoptosis of oligodendrocytes and myelin loss. In a rescue experiment, we could limit the demyelination and prevent disease progression by neutralizing the effector, TRAIL in an early stage of the disease. This is the first study to identify the accumulation of MBP antibodies in MOG induced EAE which possibly leads to TRAIL sensitized oligodendrocyte apoptosis in the white mater of EAE rats. This finding stresses on the need to study MBP antibody titers in M.S. patients and therefore might serve as an alternate marker for progressive demyelination.

Authors : Mir Sajad , Ali Farrah , Chauhan Deepika , Arora Rajesh , Khan Haider A ,

Related products :

Catalog number Product name Quantity
DL-TRAIL-Hu Human Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) ELISA Kit 96T
18-272-196986 TRAIL Receptor 3 - Goat polyclonal to TRAIL Receptor 3; Decoy receptor 1; DcR1; Decoy TRAIL receptor without death domain; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; 0.1 mg
EIAAB43690 DcR2,DCR2,Decoy receptor 2,Homo sapiens,Human,TNF-related apoptosis-inducing ligand receptor 4,TNFRSF10D,TRAIL receptor 4,TRAIL receptor with a truncated death domain,TRAILR4,TRAIL-R4,TRUNDD,Tumor nec
18-272-196987 TRAIL Receptor 2 - Goat polyclonal to TRAIL Receptor 2; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD262 antigen Polyclonal 0.1 mg
18-272-195981 DcTRAILR1 - Rabbit polyclonal to DcTRAILR1; Decoy receptor 1; DcR1; Decoy TRAIL receptor without death domain; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; Trail recep 0.1 mg
DMSI-123-X Human Sample (Multiple Sclerosis), Individual 1ml
DMSI-123-V Human Sample (Multiple Sclerosis) Individual 1unit
DMSI-123-V Human Sample (Multiple Sclerosis) Individual unit
DMSI-123-D Human Sample (Multiple Sclerosis) Individual 10ml
DMSI-123-X Human Sample (Multiple Sclerosis), individual 1 ml
DMSI-123-D Human Sample (Multiple Sclerosis) Individual 1 unit
DMSI-123-V Human Sample (Multiple Sclerosis) Individual 1 unit
20-272-190235 TRAIL - Mouse monoclonal [75411.11] to TRAIL; TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen Monoclonal 0.1 mg
20-272-190727 TRAIL - Mouse monoclonal [55B709.3] to TRAIL; TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen Monoclonal 0.05 mg
DL-TRAIL-Ra Rat Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) ELISA Kit 96T
20-272-192356 TRAIL - Mouse monoclonal [2E5] to TRAIL; TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen Monoclonal 0.1 mg
18-272-197101 TRAIL - Rabbit polyclonal to TRAIL; TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen Polyclonal 1 ml
DL-TRAIL-Mu Mouse Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) ELISA Kit 96T
DL-TRAIL-c Canine Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) ELISA Kit 96T
18-661-15037 Tumor necrosis factor receptor superfamily member 10D - Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death doma 0.1 mg
KMA1116 The cerebral dura matter and venous sinuses of dura matter, plastic pvc, Natural size
IPLA-MSPP-SER-1ml Single Donor Human Multiple Sclerosis Serum 1ml
IPLA-MSPP-SER-1ml Single Donor Human Multiple Sclerosis Serum 1ml 1ml
IPLA-MSPP-1ml Single Donor Human Multiple Sclerosis Plasma 1ml
IPLA-MSPP-1ml Single Donor Human Multiple Sclerosis Plasma 1ml 1ml


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur