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Pubmed ID :26756983
Publication Date : 2016/01/14

Increased Urinary Cystatin-C Levels Correlate with Reduced Renal Volumes in Neonates with Intrauterine Growth Restriction.


Exposure to intrauterine growth retardation (IUGR) can have a negative impact on nephrogenesis resulting in limited fetal kidney development and supporting the hypothesis that IUGR represents a risk for renal function and long-term renal disease. Cystatin-C (Cys-C), a strong inhibitor of cysteine proteinases, is freely filtered by the kidney glomerulus and is reabsorbed by the tubules, where it is almost totally catabolized; what remains is subsequently eliminated in urine. In tubular diseases and in hyperfiltration conditions, it seems reasonable to postulate that Cys-C degradation would decrease, and consequently an increase in its urinary elimination would be observed.

Authors : Barbati Antonella , Cappuccini Benito , Aisa Maria Cristina , Grasselli Chiara , Zamarra Mariarosalba , Bini Vittorio , Bellomo Gianni , Orlacchio Aldo , Di Renzo Gian Carlo ,

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