Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :27243007
Publication Date : //

Tetraspanins and Transmembrane Adaptor Proteins As Plasma Membrane Organizers-Mast Cell Case.


The plasma membrane contains diverse and specialized membrane domains, which include tetraspanin-enriched domains (TEMs) and transmembrane adaptor protein (TRAP)-enriched domains. Recent biophysical, microscopic, and functional studies indicated that TEMs and TRAP-enriched domains are involved in compartmentalization of physicochemical events of such important processes as immunoreceptor signal transduction and chemotaxis. Moreover, there is evidence of a cross-talk between TEMs and TRAP-enriched domains. In this review we discuss the presence and function of such domains and their crosstalk using mast cells as a model. The combined data based on analysis of selected mast cell-expressed tetraspanins [cluster of differentiation (CD)9, CD53, CD63, CD81, CD151)] or TRAPs [linker for activation of T cells (LAT), non-T cell activation linker (NTAL), and phosphoprotein associated with glycosphingolipid-enriched membrane microdomains (PAG)] using knockout mice or specific antibodies point to a diversity within these two families and bring evidence of the important roles of these molecules in signaling events. An example of this diversity is physical separation of two TRAPs, LAT and NTAL, which are in many aspects similar but show plasma membrane location in different microdomains in both non-activated and activated cells. Although our understanding of TEMs and TRAP-enriched domains is far from complete, pharmaceutical applications of the knowledge about these domains are under way.

Authors : Halova Ivana , Draber Petr ,

Related products :

Catalog number Product name Quantity
EIAAB24768 Allergin-1,Allergy inhibitory receptor 1,Gm885,Mast cell Ag-32,Mast cell antigen 32,Mast cell immunoglobulin-like receptor 1,Mca32,MCA-32,Milr1,Mouse,Mus musculus
EIAAB24767 Allergin-1,Allergy inhibitory receptor 1,Mast cell Ag-32,Mast cell antigen 32,Mast cell immunoglobulin-like receptor 1,Mca32,MCA-32,Milr1,Rat,Rattus norvegicus
CSB-EL024235MO Mouse T cell receptor associated transmembrane adaptor 1 (TRAT1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL024235HU Human T cell receptor associated transmembrane adaptor 1 (TRAT1) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL024235BO Bovine T cell receptor associated transmembrane adaptor 1 (TRAT1) ELISA kit, Species Bovine, Sample Type serum, plasma 96T
E2059m ELISA Alpha-chymase,Chymase,Cma1,Mast cell chymase 1,Mast cell protease 5,Mast cell protease I,Mcpt5,mMCP-5,Mouse,Mus musculus 96T
U2059m CLIA kit Alpha-chymase,Chymase,Cma1,Mast cell chymase 1,Mast cell protease 5,Mast cell protease I,Mcpt5,mMCP-5,Mouse,Mus musculus 96T
U2059m CLIA Alpha-chymase,Chymase,Cma1,Mast cell chymase 1,Mast cell protease 5,Mast cell protease I,Mcpt5,mMCP-5,Mouse,Mus musculus 96T
E2059m ELISA kit Alpha-chymase,Chymase,Cma1,Mast cell chymase 1,Mast cell protease 5,Mast cell protease I,Mcpt5,mMCP-5,Mouse,Mus musculus 96T
710537 BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-500-580-YL + M21-750-580-WT _ BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-500-580-YL + M21-750-580 1 Pcs Per Pack
710539 BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-500-580-YL + M21-750-580-WT _ BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-500-580-YL + M21-750-580 1 Pcs Per Pack
710538 BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-500-580-YL + M21-750-580-WT _ BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-500-580-YL + M21-750-580 1 Pcs Per Pack
ZRD-Mgro-case Stem Cell Products MSC medium, chemically-defined, 1 (500mlx12) case 1 case
201-20-6046 TRAT1{T cell receptor associated transmembrane adaptor 1}rabbit.pAb 0.2ml
710535 BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 +M21-1000-427 + M21-500-580-WT _ BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 +M21-1000-427 + M21-500-580-WT BG 1 Pcs Per Pack
710540 BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-1000-427 + M21-500-423 _ BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-1000-427 + M21-500-423 BG B 1 Pcs Per Pack
710536 BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 +M21-1000-427 + M21-500-580-WT _ BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 +M21-1000-427 + M21-500-580-WT BG 1 Pcs Per Pack
710542 BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-1000-427 + M21-500-423 _ BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-1000-427 + M21-500-423 BG B 1 Pcs Per Pack
710534 BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 +M21-1000-427 + M21-500-580-WT _ BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 +M21-1000-427 + M21-500-580-WT BG 1 Pcs Per Pack
710541 BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-1000-427 + M21-500-423 _ BMP21 PRINTER + HARD CASE + AC ADAPTOR + 6 BATTERIES + M21-750-499 + M21-1000-427 + M21-500-423 BG B 1 Pcs Per Pack
E13489h Human Mast Cell Expressed Membrane Protein 1 ELISA 96T
SMYD1_MOUSE Mouse ELISA Kit FOR Mast cell-expressed membrane protein 1 homolog 96T
CSB-EL003473HU Human Mast cell-expressed membrane protein 1(C19orf59) ELISA kit 96T
E0582b Mouse ELISA Kit FOR Mast cell-expressed membrane protein 1 homolog 96T
CSB-EL003473HU Human Mast cell-expressed membrane protein 1(C19orf59) ELISA kit SpeciesHuman 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur