Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :27394172
Publication Date : //

Extracellular superoxide dismutase is present in secretory vesicles of human neutrophils and released upon stimulation.


Extracellular superoxide dismutase (EC-SOD) is an antioxidant enzyme present in the extracellular matrix (ECM), where it provides protection against oxidative degradation of matrix constituents including type I collagen and hyaluronan. The enzyme is known to associate with macrophages and polymorphonuclear leukocytes (neutrophils) and increasing evidence supports a role for EC-SOD in the development of an inflammatory response. Here we show that human EC-SOD is present at the cell surface of isolated neutrophils as well as stored within secretory vesicles. Interestingly, we find that EC-SOD mRNA is absent throughout neutrophil maturation indicating that the protein is synthesized by other cells and subsequently endocytosed by the neutrophil. When secretory vesicles were mobilized by neutrophil stimulation using formyl-methionyl-leucyl-phenylalanine (fMLF) or phorbol 12-myristate 13-acetate (PMA), the protein was released into the extracellular space and found to associate with DNA released from stimulated cells. The functional consequences were evaluated by the use of neutrophils isolated from wild-type and EC-SOD KO mice, and showed that EC-SOD release significantly reduce the level of superoxide in the extracellular space, but does not affect the capacity to generate neutrophil extracellular traps (NETs). Consequently, our data signifies that EC-SOD released from activated neutrophils affects the redox conditions of the extracellular space and may offer protection against highly reactive oxygen species such as hydroxyl radicals otherwise generated as a result of respiratory burst activity of activated neutrophils.

Authors : Iversen Marie B , Gottfredsen Randi H , Larsen Ulrike G , Enghild Jan J , Praetorius Jeppe , Borregaard Niels , Petersen Steen V ,

Related products :

Catalog number Product name Quantity
EIAAB39207 EC-SOD,Extracellular superoxide dismutase [Cu-Zn],Rat,Rattus norvegicus,Sod3,Sod-3,Superoxide dismutase B
E8710h Human Superoxide Dismutase 3, Extracellular ELISA 96T
H3676 Superoxide Dismutase 3, Extracellular (SOD3), Human, ELISA Kit 96T
E90117Hu ELISA Kit for Human Superoxide Dismutase 3,Extracellular(SOD3) 96T
CSB-EL022399HU Human Extracellular superoxide dismutase [Cu-Zn](SOD3) ELISA kit 96T
E-EL-H2382 Human SOD3 (Superoxide Dismutase 3, Extracellular) ELISA Kit 96T
H1439 SOD3 (Superoxide Dismutase 3, Extracellular), Human, ELISA Kit 96T
CSB-EL022399HU Human Extracellular superoxide dismutase [Cu-Zn](SOD3) ELISA kit SpeciesHuman 96T
EIAAB39206 EC-SOD,Extracellular superoxide dismutase [Cu-Zn],Homo sapiens,Human,SOD3
SEA117Hu ELISA Kit for Superoxide Dismutase 3, Extracellular (SOD3) Homo sapiens (Human) 96T
E90117Hu ELISA Kit for Superoxide Dismutase 3, Extracellular (SOD3) Organism: Homo sapiens (Human) 96T
E90117Hu ELISA Kit for Superoxide Dismutase 3, Extracellular (SOD3) Organism Homo sapiens (Human) 96T
E0596h ELISA Homo sapiens,hSod1,Human,SOD1,Superoxide dismutase [Cu-Zn],Superoxide dismutase 1 96T
E0596h ELISA kit Homo sapiens,hSod1,Human,SOD1,Superoxide dismutase [Cu-Zn],Superoxide dismutase 1 96T
U0596h CLIA Homo sapiens,hSod1,Human,SOD1,Superoxide dismutase [Cu-Zn],Superoxide dismutase 1 96T
EH2158 Extracellular superoxide dismutase [Cu-Zn] Elisa Kit 96T
ER649 Extracellular superoxide dismutase [Cu-Zn] Elisa Kit 96T
EM1373 Superoxide Dismutase 3, Extracellular Elisa Kit 96T
P90117Hu01 Superoxide Dismutase 3, Extracellular (SOD3) Organism: Homo sapiens (Human) Source: Escherichia coli 50ug
P90117Hu01 Superoxide Dismutase 3, Extracellular (SOD3) Organism: Homo sapiens (Human) Source: Escherichia coli 100ug
P90117Hu01 Superoxide Dismutase 3, Extracellular (SOD3) Organism: Homo sapiens (Human) Source: Escherichia coli 10ug
orb81377 Human Superoxide Dismutase-1 protein Recombinant Human Cu_Zn Superoxide Dismutase produced in E.coli is a single monomeric non-glycosylated polypeptide chain containing 154 amino acids and having tota 5
E90117Rb ELISA Kit for Superoxide Dismutase 3, Extracellular (SOD3) 96T/Kit
E90117Mu ELISA Kit for Superoxide Dismutase 3, Extracellular (SOD3) 96T/Kit
E90117Hu ELISA Kit for Superoxide Dismutase 3, Extracellular (SOD3) 96T/Kit


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur