Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :27632916
Publication Date : //

Medium-chain triglycerides promote macrophage reverse cholesterol transport and improve atherosclerosis in ApoE-deficient mice fed a high-fat diet.


We previously observed that medium-chain triglycerides (MCTs) could reduce body fat mass and improve the metabolism of cholesterol. We hypothesized that MCTs can improve atherosclerosis by promoting the reverse cholesterol transport (RCT) process. Therefore, the objective of this study was to investigate the roles of MCTs in macrophage RCT and the progression of atherosclerosis. To test this hypothesis, 30 4-week-old ApoE-deficient (ApoE(-/-)) mice were randomly divided into 2 groups and fed a diet of 2% MCTs or long-chain triglycerides (LCTs) for 16 weeks. Ten age- and sex-matched C57BL/6J mice were fed a diet of 2% LCTs as the control. Macrophage-to-feces RCT was assessed in vivo by intraperitoneal injection of RAW 264.7 macrophages containing (3)H-labeled cholesterol, and atherosclerotic plaques were measured. The mRNA and protein expressions were determined by reverse transcriptase polymerase chain reaction and Western blot analyses, respectively. There was a greater decrease in body fat mass, atherosclerotic plaques, and an improvement in serum lipid profiles. In addition, the MCT mice group showed an increase in (3)H-tracer in the feces and a decrease in the liver. Significantly higher levels of mRNA and protein expression of hepatic ATP-binding cassette transporter A1, ATP-binding cassette transporter G5, cholesterol 7α-hydroxylase, and intestinal ATP-binding cassette transporter G8, as well as lower levels of expression of intestinal Niemann-Pick C1-like 1, were found in the MCT group. These results suggest that MCTs could obviously promote macrophage RCT and improve atherosclerosis in ApoE(-/-) mice, indicating that MCTs have the potential to prevent cardiovascular disease.

Authors : Zhang Xinsheng , Zhang Yong , Liu Yinghua , Wang Jin , Xu Qing , Yu Xiaoming , Yang Xueyan , Liu Zhao , Xue Changyong ,

Related products :

Catalog number Product name Quantity
29-624 LCAT is an extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in its gene have been 0.1 mg
TM 415 CARRY _ BLAIR MEDIUM BASE (TRANSPORT MEDIUM W_O. CHARCOAL, CARRY & BLAIR TRANSPORT MEDIUM) (a holding medium for clinical specimens during collection 500 gm
TM 415 CARRY _ BLAIR MEDIUM BASE (TRANSPORT MEDIUM W_O. CHARCOAL, CARRY & BLAIR TRANSPORT MEDIUM) (a holding medium for clinical specimens during collection 100 gm
TM 415 CARRY _ BLAIR MEDIUM BASE (TRANSPORT MEDIUM W_O. CHARCOAL, CARRY & BLAIR TRANSPORT MEDIUM) (a holding medium for clinical specimens during collection 100 gm
TM 415 CARRY _ BLAIR MEDIUM BASE (TRANSPORT MEDIUM W_O. CHARCOAL, CARRY & BLAIR TRANSPORT MEDIUM) (a holding medium for clinical specimens during collection 500 gm
PCR-235S Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: High Fidelity Hot Start Core Kit, S pack Kit of heat-activatable DNA polymerase for high accuracy and 100units
PCR-235L Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: High Fidelity Hot Start Core Kit, L pack Kit of Heat-activatable DNA polymerase for high accuracy and 500units
PCR-205S Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: High Fidelity Hot Start Pol, S pack Heat-activatable DNA polymerase for high accuracy and specificity 100units
PCR-205L Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: High Fidelity Hot Start Pol, L pack Thermostable DNA polymerase for high accuracy and specificity 500units
PCR-204S Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: High Fidelity Pol, S pack DNA polymerase for high accuracy 100units
PCR-204L Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: High Fidelity Pol, L pack DNA polymerase for high accuracy 500units
PCR-234L Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: High Fidelity Core Kit, L pack Kit of DNA polymerase for high accuracy, dNTPs and reaction buffer 500units
PCR-234S Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: High Fidelity Core Kit, S pack Kit of DNA polymerase for high accuracy, dNTPs and reaction buffer 100units
PCR-231S-red Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: Taq Core Kit _ high yield, red - S pack Kit of thermostable DNA polymerase, dNTPs and high yield buff 200units
PCR-231S Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: Taq Core Kit _ high yield, S pack Kit of thermostable DNA polymerase, dNTPs and high yield buffer 200units
PCR-231L-red Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: Taq Core Kit _ high yield, red - L pack Kit of thermostable DNA polymerase, dNTPs and high yield buff 1000units
PCR-231L Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: Taq Core Kit _ high yield, L pack Kit of thermostable DNA polymerase, dNTPs and high yield buffer 1000units
TM 420 TRANSPORT MEDIUM, STUART (STUART TRANSPORT MEDIUM) (for preservation and transportation of Neisseria species and other fastidious organisms.) 500 gm
TM 420 TRANSPORT MEDIUM, STUART (STUART TRANSPORT MEDIUM) (for preservation and transportation of Neisseria species and other fastidious organisms.) 100 gm
B147 Stuart Transport Medium w_o Sodium Glycerophosphate USE With addition of Sodium glycerophosphate, medium is used for routine transport of Gonococcus species and other fastidious organisms. Qty per Litre of Medium: 4
B147 Stuart Transport Medium w_o Sodium Glycerophosphate USE : With addition of Sodium glycerophosphate, medium is used for routine transport of Gonococcus species and other fastidious organisms. 5x500gm
PCR-155L-FTP Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: Taq Master Lyophilisate _ high yield, preloaded 96-well platesflat top _ without skirt Lyophilized Ta 10plates
PCR-155S-FTP Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: Taq Master Lyophilisate _ high yield, preloaded 96-well platesflat top _ without skirt Lyophilized Ta 2plates
PCR-154L-HSP Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: Red Load Taq Master Lyophilisate _ high yield, preloaded 96-well plateshalf skirt Lyophilized Taq Mas 10plates
PCR-154S-HSP Polymerase chain reaction PCR and reverse transcriptase polymerase chain reaction RT PCR products: Red Load Taq Master Lyophilisate _ high yield, preloaded 96-well plateshalf skirt Lyophilized Taq Mas 2plates


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur