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Pubmed ID :27733247
Publication Date : //

Klotho response to treatment with growth hormone and the role of IGF-I as a mediator.


Klotho is an aging-modulating protein expressed mainly in the kidneys, which can be cleaved and shed to act as a circulating hormone. Several lines of evidence suggest a tight interaction between klotho and the GH-IGF-I axis. We showed previously that klotho levels are decreased in pediatric patients with growth hormone deficiency (GHD). Our aim now is to investigate the effect of GH therapy on klotho levels in these patients and to elucidate the role of IGF-1 in mediating secretion of klotho.

Authors : Rubinek Tami , Shahmoon Shiri , Shabtay-Orbach Ayelet , Ben Ami Michal , Levy-Shraga Yael , Mazor-Aronovitch Kineret , Yeshayahu Yonatan , Doolman Ram , Hemi Rina , Kanety Hannah , Wolf Ido , Modan-Moses Dalit ,

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