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Pubmed ID :27888757
Publication Date : //

BMP4/Id2 signaling pathway is a novel therapeutic target for late outgrowth endothelial progenitor cell-mediated endothelial injury repair.


Endothelial progenitor cells (EPCs) play a pivotal role in endothelial repair following artery injury, however, the molecular mechanism of late outgrowth EPCs (LEPCs) in endothelial repair remained to be studied. Bone morphogenetic protein 4 (BMP4) is involved in vascular injury-mediated mobilization and homing of LEPCs. Here, we investigated the influence of BMP4-modified signaling pathway in LEPC-related endothelial repair of human and underlying molecular mechanism.

Authors : Xia Wen-Hao , Chen Long , Liang Jian-Wen , Zhang Xiao-Yu , Su Chen , Tong Xinzhu , He Jiang , Li Yan , Cao Zheng , Lin Xiu-Fang , Tao Jun ,

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