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Pubmed ID :27941311
Publication Date : //

β-Klotho as a Negative Regulator of the Peptide Transporters PEPT1 and PEPT2.


β-Klotho, a transmembrane protein expressed in several tissues including the brain and the kidney, is critically important for inhibition of 1,25(OH)2D3 formation by FGF23. The extracellular domain of Klotho protein could be cleaved off, thus being released into blood or cerebrospinal fluid. Soluble klotho is a β-glucuronidase participating in the regulation of several ion channels and carriers. The present study explored the effect of β-Klotho protein on the peptide transporters PEPT1 and PEPT2.

Authors : Abousaab Abeer , Warsi Jamshed , Salker Madhuri S , Lang Florian ,

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