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Pubmed ID :27986651
Publication Date : //

Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans.


Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptors as the basis for LDL lowering by PCSK9 inhibitors, there have been no human studies characterizing the effects of PCSK9 inhibitors on lipoprotein metabolism. In particular, it is not known whether inhibition of PCSK9 has any effects on very low-density lipoprotein or intermediate-density lipoprotein (IDL) metabolism. Inhibition of PCSK9 also results in reductions of plasma lipoprotein (a) levels. The regulation of plasma Lp(a) levels, including the role of LDL receptors in the clearance of Lp(a), is poorly defined, and no mechanistic studies of the Lp(a) lowering by alirocumab in humans have been published to date.

Authors : Reyes-Soffer Gissette , Pavlyha Marianna , Ngai Colleen , Thomas Tiffany , Holleran Stephen , Ramakrishnan Rajasekhar , Karmally Wahida , Nandakumar Renu , Fontanez Nelson , Obunike Joseph , Marcovina Santica M , Lichtenstein Alice H , Matthan Nirupa R , Matta James , Maroccia Magali , Becue Frederic , Poitiers Franck , Swanson Brian , Cowan Lisa , Sasiela William J , Surks Howard K , Ginsberg Henry N ,

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