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Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation. Adipocytes formed from human keloid fibroblasts either when treated with BMP or when placed with human hair follicles in vitro Thus, we identify the myofibroblast as a plastic cell type that may be manipulated to treat scars in humans.
Authors : Plikus Maksim V , Guerrero-Juarez Christian F , Ito Mayumi , Li Yun Rose , Dedhia Priya H , Zheng Ying , Shao Mengle , Gay Denise L , Ramos Raul , Hsi Tsai-Ching , Oh Ji Won , Wang Xiaojie , Ramirez Amanda , Konopelski Sara E , Elzein Arijh , Wang Anne , Supapannachart Rarinthip June , Lee Hye-Lim , Lim Chae Ho , Nace Arben , Guo Amy , Treffeisen Elsa , Andl Thomas , Ramirez Ricardo N , Murad Rabi , Offermanns Stefan , Metzger Daniel , Chambon Pierre , Widgerow Alan D , Tuan Tai-Lan , Mortazavi Ali , Gupta Rana K , Hamilton Bruce A , Millar Sarah E , Seale Patrick , Pear Warren S , Lazar Mitchell A , Cotsarelis George ,
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