Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Publication Date : //
Response of Novel Skeletal Muscle Biomarkers in Dogs to Drug-Induced Skeletal Muscle Injury or Sustained Endurance Exercise.
The skeletal muscle (SKM) injury biomarkers, skeletal troponin I (sTnI), myosin light chain 3 (Myl3), and creatine kinase muscle isoform (Ckm) have been shown recently to be more sensitive and specific for monitoring drug-induced SKM injury than the conventional biomarkers, aspartate transaminase (AST) and creatine kinase (CK) enzymatic assays in rat toxicology studies. To evaluate the utility of these SKM biomarkers across species, they were assessed in 2 dog models: a drug-induced injury study in Beagle dogs and a 160 km endurance exercise run completed by Alaskan sled dogs. In the drug-induced injury model, mean sTnI and Myl3 plasma levels were 6- and 18-fold, respectively, compared with baseline as early as Study Day (SD) 15, while mean plasma AST and CK levels did not increase, and biopsy samples were non-remarkable for histopathology prior to SD 29 when degeneration was first noted. Peak group mean plasma responses over baseline for sTnI, Myl3, and Ckm biomarkers were 96-, 103-, and 11-fold, respectively, compared with 2.5-fold for AST and 3.8-fold for CK-enzymatic (CK-enz) assay. In the sled dog sustained exercise model, the peak response for all biomarkers was observed at the first sampling (2 h) after the completion of the run. The sTnI, Myl3, and Ckm mean fold peak values compared with baseline were 170-, 120-, and 150-fold, respectively, while AST increased 7-fold and CK-enz increased 29-fold. These findings support the conclusion that sTnI, Myl3, and Ckm are sensitive early tissue leakage biomarkers for monitoring SKM injury and effects of exercise in dog, extending their utility across preclinical species beyond the rat, and provide further support to investigate their translational utility to clinical trial settings to monitor for drug-induced SKM injury and ensure patient safety.
Authors : Vlasakova Katerina , Lane Pamela , Michna Laura , Muniappa Nagaraja , Sistare Frank D , Glaab Warren E ,
Related products :
52062 Aachen Deutschland
Support Karolina Elandt
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
firstname.lastname@example.org | Gentaur
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Finland Helsset +358942419041
Magyarország Budapest +3619980547
US New York+17185132983
WP1088: Striated Muscle Contraction
WP1316: Striated Muscle Contraction
WP1403: AMPK signaling
WP1864: Muscle contraction
WP1946: Cori Cycle
WP1991: SRF and miRs in Smooth Muscle Differentiation and Proliferation
WP2005: Muscle cell TarBase
WP2012: miRs in Muscle Cell Differentiation
WP2076: miRs in Muscle Cell Differentiation
WP2081: SRF and miRs in Smooth Muscle Differentiation and Proliferation
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP216: Striated Muscle Contraction
WP316: Striated Muscle Contraction
WP383: Striated Muscle Contraction
WP745: Striated Muscle Contraction
WP850: Striated Muscle Contraction
WP969: Striated Muscle Contraction
WP1040: Inflammatory Response Pathway
WP1108: Hypothetical Network for Drug Addiction
WP1113: Cytokines and Inflammatory Response
WP1156: Inflammatory Response Pathway
WP1246: Hypothetical Network for Drug Addiction
WP1281: Hypothetical Network for Drug Addiction
WP1333: Hypothetical Network for Drug Addiction
WP1527: stress response
Related Genes :
 Exercise patterns in older adults instructed to follow moderate- or high-intensity exercise protocol - the generation 100 study.
 Short-Term Preconditioning With Blood Flow Restricted Exercise Preserves Quadriceps Muscle Endurance in Patients After Anterior Cruciate Ligament Reconstruction.
 Burden of ventricular arrhythmias at 12-lead 24-hour ambulatory ECG monitoring in middle-aged endurance athletes versus sedentary controls.
 High intensity, circuit-type integrated neuromuscular training alters energy balance and reduces body mass and fat in obese women: A 10-month training-detraining randomized controlled trial.
 Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity.
 A new conceptual framework for the integrated neural control of locomotor and sympathetic function: implications for exercise after spinal cord injury.
 Martin Vigorimeter assesses muscle fatigability in older adults better than the Jamar Dynamometer.
 Effect of Endurance Conditioning on Insulin-mediated Glucose Clearance in Dogs.
 A brief pre-exercise nap may alleviate physical performance impairments induced by short-term sustained operations with partial sleep deprivation - A field-based study.
 The Effect of Quantity and Quality of Pre-Exercise Carbohydrate Meals on Central Fatigue.
Enter catalog number :