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Pubmed ID :28266038
Publication Date : //

Using direct antiglobulin test results to reduce unnecessary cold agglutinin testing.


Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia mediated by autoantibodies that preferentially react at 4°C. Laboratory testing for cold-reactive autoantibodies is laborious and may not be ordered judiciously, particularly in patients with a negative direct antiglobulin test (DAT). We sought to determine whether a negative DAT using anti-human complement (anti-C3) rules out elevated cold agglutinin (CA) titers and the diagnosis of CAD.

Authors : Wilen Craig B , Booth Garrett S , Grossman Brenda J , Lane William J , Szklarski Penny C , Jackups Ronald ,

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