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Pubmed ID :28286870
Publication Date : 2017/03/13

D-amino acids do not inhibit Pseudomonas aeruginosa biofilm formation.


Pseudomonas aeruginosa, a known biofilm-forming organism, is an opportunistic pathogen that plays an important role in chronic otitis media, tracheitis, cholesteatoma, chronic wounds, and implant infections. Eradication of biofilm infections has been a challenge because the biofilm phenotype provides bacteria with a protective environment from the immune system and antibiotics; thus, there has been great interest in adjunctive molecules that may inhibit biofilm formation or cause biofilm dispersal. There are reports that D-amino acids may inhibit biofilms. In this study, we test the ability of various D-amino acids to inhibit P. aeruginosa biofilm formation in vitro.

Authors : Kao Wee Tin K , Frye Mitchell , Gagnon Patricia , Vogel Joseph P , Chole Richard ,

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