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Pubmed ID :28449660
Publication Date : //

Selective measurement of α smooth muscle actin: why β-actin can not be used as a housekeeping gene when tissue fibrosis occurs.


Prevalence of fibroproliferative diseases, including chronic kidney disease is rapidly increasing and has become a major public health problem worldwide. Fibroproliferative diseases are characterized by increased expression of α smooth muscle actin (α-SMA) that belongs to the family of the six conserved actin isoforms showing high degree homology. The aim of the present study was to develop real-time PCRs that clearly discriminate α-SMA and ß-actin from other actin isoforms.

Authors : Veres-Székely Apor , Pap Domonkos , Sziksz Erna , Jávorszky Eszter , Rokonay Réka , Lippai Rita , Tory Kálmán , Fekete Andrea , Tulassay Tivadar , Szabó Attila J , Vannay Ádám ,

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